Toxic effects of deltamethrin on oxidative stress, behavioural, organosomatic indices and histopathological changes in Digitonthophagus gazella (Coleoptera: Scarabaeinae)

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-22 DOI:10.1016/j.etap.2025.104642

Nishi Pandya , Ankita Salunke , Pankaj Sharma , Parth Pandya , Pragna Parikh

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Abstract

Pyrethroids pose a great concern to the declining population of dung beetles and the sustainability of ecosystem services. This study aimed to investigate the toxic effects of deltamethrin on Digitonthophagus gazella. First, the LC₅₀ value (0.275 ppm) was determined, and sub-lethal concentrations (LD; low dose-0.014ppm, MD; medium dose-0.028ppm, and HD; high dose-0.055ppm) were assessed for physiological effects. The findings showed a significant dose and time dependent increase in fluorescence intensity (DCF-DA staining) and a decrease in antioxidant activity, including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Furthermore, significant down regulation of cyp4g7, cyp6bq9, and cyp4q4 expression indicates enhanced oxidative stress. Additionally, a reduction in the organosomatic index, accompanied by histological changes in the brain, gut, and gonads, suggests potential functional disturbances. Overall, deltamethrin exposure had profound and irreversible pathological consequences on various vital organs and systems in D. gazella, affecting reproduction and nesting.

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溴氰菊酯对 Digitonthophagus gazella（鞘翅目：猩红蛾科）氧化应激、行为、有机体指数和组织病理学变化的毒性效应。

拟除虫菊酯对屎壳虫数量的减少和生态系统服务的可持续性造成了严重的影响。本研究旨在探讨溴氰菊酯对食地黄鳝的毒性作用。首先，测定LC50值（0.275 ppm），亚致死浓度(LD；低剂量-0.014ppm， MD；中剂量-0.028ppm， HD；高剂量（0.055ppm）评估生理效应。结果显示，荧光强度（dcfda染色）呈剂量和时间依赖性增加，抗氧化活性（包括超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽（GSH））下降。此外，cyp4g7、cyp6bq9和cyp4q4表达显著下调表明氧化应激增强。此外，机体指数降低，并伴有脑、肠和性腺的组织学变化，提示潜在的功能障碍。总体而言，溴氰菊酯暴露对gazella的多个重要器官和系统产生了深刻且不可逆的病理影响，影响了繁殖和筑巢。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.