Erenumab in a patient with persistent headaches after subarachnoid hemorrhage: A case report of an effective treatment.

IF 5.4 2区 医学 Q1 CLINICAL NEUROLOGY Headache Pub Date : 2025-01-26 DOI:10.1111/head.14884
Ajay Gandhi, Travis R Quinoa, Eric Geller, Priyank Khandelwal, Pankaj K Agarwalla
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Abstract

A patient with persistent refractory headaches from aneurysmal subarachnoid hemorrhage was treated with monthly erenumab injections, a monoclonal antibody to the calcitonin gene-related peptide (CGRP) receptor. These injections decreased the frequency and severity of the patient's debilitating headaches from daily to once or twice per month with positive improvement in function and quality of life. To our knowledge, this is the first reported case in the literature of a patient with persistent post-subarachnoid hemorrhage headache that was successfully treated with an antibody against the CGRP receptor. This case report highlights the role of CGRP in post-subarachnoid hemorrhage headaches and the potential role for CGRP pathway-based therapies as an effective treatment.

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来源期刊
Headache
Headache 医学-临床神经学
CiteScore
9.40
自引率
10.00%
发文量
172
审稿时长
3-8 weeks
期刊介绍: Headache publishes original articles on all aspects of head and face pain including communications on clinical and basic research, diagnosis and management, epidemiology, genetics, and pathophysiology of primary and secondary headaches, cranial neuralgias, and pains referred to the head and face. Monthly issues feature case reports, short communications, review articles, letters to the editor, and news items regarding AHS plus medicolegal and socioeconomic aspects of head pain. This is the official journal of the American Headache Society.
期刊最新文献
Erenumab in a patient with persistent headaches after subarachnoid hemorrhage: A case report of an effective treatment. A randomized sequential cross-over trial evaluating five purportedly ICP-lowering drugs in idiopathic intracranial hypertension. Sex differences in pain, suicidal ideation, and suicide attempts in patients with migraine. Today in headache medicine: Helpful analogies in headache medicine. Development of the Migraine-Related Stigma (MiRS) Questionnaire: Results of the OVERCOME (US) Study.
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