Changes in the treatment and outcomes of different severities of neonatal hypoxic ischemic encephalopathy in California: a retrospective cohort study

IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2025-01-26 DOI:10.1038/s41372-025-02212-5
Carolyn Fall, Rebecca J. Baer, Henry C. Lee, Gretchen Bandoli, Christina D. Chambers
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Abstract

Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE). Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010–2015) and Epoch 2 (2016–2019). Risk ratios (RR) for induced hypothermia (IH) in each epoch and their outcomes were calculated using log-linear regression. In this cohort, 4779 infants with HIE were identified. Incidence of HIE in California increased yearly from 0.5/1000 California births to a peak of 1.5/1000 births in 2018. The use of IH in infants with mild HIE increased in Epoch 2 compared to Epoch 1. There was no significant difference in outcomes between epochs for infants with mild HIE that received IH including no difference in neonatal seizures. Significantly more infants with mild HIE received IH since 2015 in California, but no significant difference in outcomes.

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加利福尼亚不同程度新生儿缺氧缺血性脑病的治疗和预后的变化:一项回顾性队列研究。
目的:评价加州婴儿缺氧缺血性脑病(HIE)的治疗和预后的变化。研究设计:使用ICD代码从加州行政出生队列中确定HIE婴儿,并将其分为两个时期,第1时期(2010-2015年)和第2时期(2016-2019年)。采用对数线性回归计算各时期诱发性低温(IH)的风险比(RR)及其结果。结果:在该队列中,发现4779例HIE患儿。加州HIE的发病率每年从0.5/1000上升到2018年的峰值1.5/1000。在轻度HIE患儿中,IH的使用在第2期比第1期增加。接受IH治疗的轻度HIE婴儿在不同时期的结局没有显著差异,包括新生儿癫痫发作没有差异。结论:自2015年以来,加利福尼亚州轻度HIE婴儿接受IH治疗的人数明显增加,但结局无显著差异。
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来源期刊
Journal of Perinatology
Journal of Perinatology 医学-妇产科学
CiteScore
5.40
自引率
6.90%
发文量
284
审稿时长
3-8 weeks
期刊介绍: The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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