Building a Bridge Between the Mechanism of EBV Reactivation and the Treatment of EBV-Associated Cancers

IF 4.6 3区医学 Q1 VIROLOGY Journal of Medical Virology Pub Date : 2025-01-27 DOI:10.1002/jmv.70192

Jialin Jiang, Xinlei Zhu, Shukun Li, Qun Yan, Jian Ma

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Abstract

Epstein-Barr virus (EBV) infection is closely associated with the development of various tumors such as lymphomas and epithelial cancers. EBV has a discrete life cycle with latency and lytic phases. In recent years, significant progress has been made in the understanding of the mechanism underlying the transition of EBV from latency to lytic replication. Multiple new lytic activation factors have been emerged and promoted our understanding of this field. In addition, we have comprehensively presented the existing therapeutic strategies and their relationship to the mechanism underlying the transition of EBV from latency to lytic replication in this review, such as lytic induction therapy and drugs to prevent EBV from entering the lytic phase fully utilize the EBV reactivation mechanisms. This year marks the 60th anniversary of the discovery of EBV, and building a bridge between the mechanism of EBV reactivation and the treatment may help us to design new approaches for treating EBV-associated diseases.

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建立EBV再激活机制与EBV相关癌症治疗之间的桥梁。

eb病毒（EBV）感染与各种肿瘤的发展密切相关，如淋巴瘤和上皮癌。EBV有一个离散的生命周期，有潜伏期和裂解期。近年来，在了解EBV从潜伏期向裂解复制转变的机制方面取得了重大进展。许多新的裂解活化因子的出现促进了我们对这一领域的认识。此外，我们还全面介绍了现有的治疗策略及其与EBV从潜伏期向裂解复制转变的机制之间的关系，如裂解诱导疗法和阻止EBV进入裂解期的药物，以充分利用EBV的再激活机制。今年是EBV发现60周年，在EBV再激活机制和治疗之间建立桥梁可能有助于我们设计治疗EBV相关疾病的新方法。

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.