Association between Pre-pregnancy BMI and Pregnancy Outcomes in Women with Gestational Diabetes: A Retrospective Cohort Study.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Pakistan Journal of Medical Sciences Pub Date : 2025-01-01 DOI:10.12669/pjms.41.1.10920

Lianghui Zheng, Qiuping Liao, Jiaoxia Liu, Jun Shi, Zihua Chen, Lin Lin

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Abstract

Background & objective: The specific influence of the pre-pregnancy body mass index (PPBMI) on women with gestational diabetes mellitus (GDM) is unclear. Our objective was to investigate how PPBMI categories affect pregnancy and neonatal outcomes in women with GDM.

Methods: A retrospective cohort study was conducted using data from patients attending the Fujian Maternity and Child Health Hospital (Fuzhou, China) from 2021 to 2023. The participant records were stratified into four groups according to their BMI values: underweight, normal-weight, overweight, and obese. The pregnancy and neonatal outcomes for these BMI categories were analyzed using multivariable logistic regression.

Results: The study included data from 2,909 pregnant women diagnosed with GDM. Underweight women with GDM showed significantly lower risks of pregnancy-induced hypertension (PIH) (adjusted OR, 0.26) and cesarean sections (adjusted OR, 0.55) but higher risks of low body weight (LBW) infants (adjusted OR, 3.40). Overweight and obese women experienced higher risks of PIH (adjusted OR, 2.96), cesarean sections (adjusted OR, 1.62), and macrosomia (adjusted OR, 1.43).

Conclusion: PPBMIs significantly impact pregnancy outcomes in women with GDM. Both underweight and overweight/obese categories are associated with adverse outcomes, highlighting the need for pre-pregnancy counseling and interventions to achieve and maintain a healthy BMI.

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妊娠期糖尿病患者孕前BMI与妊娠结局的关系：一项回顾性队列研究

背景与目的：孕前体重指数（PPBMI）对妊娠期糖尿病（GDM）的具体影响尚不清楚。我们的目的是研究PPBMI类别如何影响GDM妇女的妊娠和新生儿结局。方法：对福建省妇幼保健院（中国福州）2021年至2023年住院患者的数据进行回顾性队列研究。参与者的记录根据他们的BMI值被分为四组：体重过轻、体重正常、超重和肥胖。使用多变量logistic回归分析这些BMI类别的妊娠和新生儿结局。结果：该研究纳入了2909名诊断为GDM的孕妇的数据。体重过轻的GDM女性发生妊高征（PIH）（校正OR， 0.26）和剖宫产（校正OR， 0.55）的风险显著降低，但低体重儿（LBW）的风险较高（校正OR， 3.40）。超重和肥胖妇女发生妊高征（校正OR， 2.96）、剖宫产（校正OR， 1.62）和巨大儿（校正OR， 1.43）的风险较高。结论：ppbmi对GDM患者妊娠结局有显著影响。体重不足和超重/肥胖类别都与不良后果有关，这突出了孕前咨询和干预措施的必要性，以实现和保持健康的体重指数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.