Fernanda Cesar Dos Santos, Matheus Menão Mochetti, Cíntia Kazuko Tokuhara, Adriano de Souza Pessoa, Kelly Karina Inacio, Mariana Liessa Rovis Sanches, Valdecir Farias Ximenes, Rodrigo Cardoso de Oliveira
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引用次数: 0
Abstract
Osteosarcoma is the most common primary bone cancer, accounting for approximately 5 % of new cancer cases globally. In contrast, breast cancer remains the most prevalent malignancy and a leading cause of cancer-related mortality among women. Given the limitations of current therapies, novel treatment strategies are urgently needed. This study evaluates the effects of diapocynin, a derivative of apocynin, on osteosarcoma (UMR-106) and breast cancer (MDA-MB-231) cell lines. Our results demonstrate a dose-dependent cytotoxicity of diapocynin in both cell types, with UMR-106 cells showing higher sensitivity than MDA-MB-231 cells. Notably, treatment with diapocynin induced significant morphological changes in both cell lines, and both IC25 and IC50 concentrations effectively inhibited cell migration, particularly in osteosarcoma cells. However, no significant changes were detected in matrix metalloproteinases -2 and -9 activity following treatment, suggesting that diapocynin may exert its effects through alternative pathways. These results highlight diapocynin as a promising candidate for cancer therapy, warranting further investigation into its mechanisms of action and potential clinical applications.
期刊介绍:
Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed.
Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.