The Effect of Zinc Supplementation on Glycemic, Weight, and Blood Pressure Control in Patients With Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Trial

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL Health Science Reports Pub Date : 2025-01-23 DOI:10.1002/hsr2.70375

Mehrab Sayadi, Sara Javadpour Nowbandegani, Fatemeh Balaghi Inalou, Bahman Nazemzadegan, Shirzad Javidi Alsaadi, Mohammadreza Eskandari, Matin Sepehrinia

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Abstract

Backgrounds and Aims

Type 2 diabetes and its complications are assumed to be major public health problems globally. Zinc is one of the elements that play a part in insulin secretion and signaling. Therefore, this study seeks the answer to the following question: “What are the effects of 220 mg zinc sulfate supplementation on the weight, blood pressure, and glycemic control of patients with Type 2 diabetes?”.

Methods

In this randomized controlled double-blind trial, 79 patients with Type 2 diabetes were allocated into two groups through permuted block randomization method. The study group received two capsules of 220 mg of zinc sulfate containing 50 mg of zinc, and the control group received two capsules of 220 mg of placebo ingredient per week for 12 weeks. At the start and end of the treatment period, the fasting blood glucose (FBG), glycated hemoglobin (HbA1c), zinc level, weight, waist circumference (WC), and blood pressure were measured.

Results

After 12 weeks of follow-up, 72 patients completed the study. There were no significant differences before and after the intervention in the FBG, HbA1c, zinc levels, and WC between the two groups. Intragroup analysis showed that weight and body mass index increased in the intervention group; however, these changes were not significant in comparison to the control group. Also, diastolic blood pressure significantly increased in the control group; however, changes in systolic blood pressure were not significant in both groups.

Conclusion

Taking 220 mg of zinc sulfate supplement twice a week did not show significant benefit for weight, blood pressure, and glycemic control in patients with Type 2 diabetes.

Trial Registration

This trial was registered on the Iranian Registry of Clinical Trials (IRCT) website with code number 29627 on September 18, 2018.

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补充锌对2型糖尿病患者血糖、体重和血压控制的影响：一项双盲随机对照试验

背景和目的：2型糖尿病及其并发症被认为是全球主要的公共卫生问题。锌是在胰岛素分泌和信号传导中起作用的元素之一。因此，本研究寻求以下问题的答案：“补充220毫克硫酸锌对2型糖尿病患者的体重、血压和血糖控制有什么影响？”方法：采用排列块随机法将79例2型糖尿病患者随机分为两组。研究组服用含50毫克锌的220毫克硫酸锌胶囊两粒，对照组服用含220毫克安慰剂成分的胶囊两粒，持续12周。在治疗期开始和结束时，测量空腹血糖（FBG）、糖化血红蛋白（HbA1c）、锌水平、体重、腰围（WC）和血压。结果：随访12周后，72例患者完成研究。干预前后两组患者FBG、HbA1c、锌水平、WC均无显著差异。组内分析显示，干预组体重和体质指数升高；然而，与对照组相比，这些变化并不显著。同时，对照组的舒张压显著升高；然而，两组的收缩压变化并不显著。结论：每周服用两次220毫克硫酸锌补充剂对2型糖尿病患者的体重、血压和血糖控制没有显着益处。试验注册：该试验于2018年9月18日在伊朗临床试验注册中心（IRCT）网站上注册，代码为29627。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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