Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended-Spectrum β-Lactamase at a Tertiary Central Hospital in Saudi Arabia

Abstract

Background and Aims

Urinary tract infections (UTIs) are a prevalent bacterial infection that has substantial implications for healthcare on a global scale. Escherichia coli (E. coli) is a gram-negative rod responsible for most UTI cases. ESBL-producing E. coli is widely recognized as a significant contributor to antibiotic resistance. This study aims to evaluate the prevalence and antibiotic resistance trends of ESBL-producing E. coli in patients with UTIs at a tertiary hospital in Jazan, Saudi Arabia.

Methods

A retrospective cross-sectional analysis was conducted on 347 urine specimens collected between January 2022 and March 2023.

Results

The study found that 31% of E. coli specimens were positive for ESBL. Among patients with ESBL-producing E. coli, 78.9% were females, and the majority of ESBL-producing E. coli cases were observed in the outpatient clinic departments. Among all E. coli isolates, ampicillin exhibited the highest resistance rate at 69.3%, aztreonam at 66.7%, and colistin at the lowest resistance. ESBL-producing E. coli strains exhibited higher resistance rates than non-ESBL-producing E. coli strains.

Conclusion

The study agrees with others in the region and shows a higher prevalence of ESBL-producing E. coli in the region, emphasizing the importance of antibiotic stewardship programs and infection control measures to mitigate the prevalence and spread of ESBL-producing E. coli in our region.