Neurodevelopmental Follow-Up in Children with Intrauterine and Perinatal Exposure to Chikungunya Virus.

Abstract

Objective: To investigate the effects of intrauterine and perinatal exposure to chikungunya virus (CHIKV) on neurodevelopment in infants and toddlers.

Study design: We conducted a cohort study comparing children with intrauterine or perinatal exposure to maternal CHIKV infection with unexposed controls in Rio de Janeiro, Brazil. Neurodevelopment was assessed with General Movement Assessments (GMA) in the first six months of life, and the Bayley-III Scales of Infant and Toddler Development and Modified Checklist for Autism in Toddlers (M-CHAT) for older children. Developmental delay (DD) was defined as a Bayley score less than 70 and risk of DD as a score less than 85.

Results: Among 60 children exposed to intrauterine or perinatal CHIKV, 20 (33 %) had laboratory confirmation of CHIKV infection by RT-PCR or IgM serology and 40 did not; 44 exposed children (15 infected and 29 uninfected) had GMA performed, with 19% having suboptimal or abnormal results. At 11 to 42 months of age, 35 exposed children and 78 unexposed controls had Bayley-III assessments. Compared with controls, exposed children had higher rates of DD (7 [20%] vs. 2 [3%], p=0.004) driven by the language domain, and greater risk of DD driven by motor and cognitive domains scores (10 [29%] vs. 10 [13%], p=0.03 and 8 [23%] vs. 5 [6%], p=0.02, respectively). Eight of 35 (23%), CHIKV exposed children screened positive for autism spectrum disorder. CHIKV-exposed uninfected children had 2 (9.5%) cases of DD and 5 (23.8%) cases of ASD.

Conclusions: Abnormal neurodevelopmental results were seen in both infected and uninfected children with intrauterine or perinatal CHIKV exposure. Infant neurodevelopment monitoring should be considered following exposure to maternal CHIKV infection in pregnancy to facilitate early interventions and to mitigate neurodevelopmental sequelae.