The association of medical cannabis use with quality of life in Illinois' opioid alternative pilot program.

Cerina Dubois, Julie Bobitt, Lei Ding, Dean T Eurich, Ashley A Knapp, Neil Jordan
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Abstract

Background: In Illinois, the Opioid Alternative Pilot Program (OAPP) was launched to expand access to medical cannabis to use as a direct substitute for opioids. Although therapeutic benefits have been reported in reducing opioid use, there is an absence of literature that examines how medical cannabis use impacts an individual's quality of life (QoL). This study examines the association of medical cannabis use with QoL among the first enrollees in OAPP.

Methods: A survey was sent to enrollees between February and July 2019. Cannabis users (n=626) were compared to non-users (n=234) to determine whether there was an association between cannabis use within the past year and QoL. Ordered logistic regression and backwards stepwise regression modelling was used.

Results: Across the study sample of 860 participants, the average age was 47 years; 60 % of the cohort was male; 72 % were not of Hispanic, Latino, or Spanish origin; 67 % were married. Across the entire study sample, the average perceived QoL was 2.86 (between 'Good' and 'Fair'), with no statistically significant difference in QoL between the two groups (non-users: 2.85; cannabis users: 2.86; p=0.92). Logistic regression reported cannabis use within the past year did not have a statistically significant association with QoL (OR=1.33, 95% confidence interval, 0.85 to 2.08, p=0.21).

Discussion: Overall, there was no significant association between cannabis use within the past year and QoL. This may be attributed to pain being a qualifying condition to enter the program.

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伊利诺伊州阿片类药物替代试点项目中医用大麻使用与生活质量的关系。
背景:在伊利诺伊州,启动了阿片类药物替代试点方案(OAPP),以扩大获得医用大麻的机会,将其用作阿片类药物的直接替代品。虽然已经报道了减少阿片类药物使用的治疗益处,但缺乏研究医用大麻使用如何影响个人生活质量的文献。本研究探讨了医用大麻的使用与生活质量在OAPP的第一个注册者之间的关系。方法:在2019年2月至7月期间向入组者发送调查问卷。将大麻使用者(n=626)与非使用者(n=234)进行比较,以确定过去一年内大麻使用与生活质量之间是否存在关联。采用有序逻辑回归和反向逐步回归模型。结果:在860名参与者的研究样本中,平均年龄为47岁;60%的研究对象为男性;72%的人不是西班牙裔、拉丁裔或西班牙裔;67%的人已婚。在整个研究样本中,平均感知生活质量为2.86(在“好”和“一般”之间),两组之间的生活质量没有统计学上的显著差异(非用户:2.85;大麻使用者:2.86;p = 0.92)。Logistic回归报告,过去一年内使用大麻与生活质量没有统计学意义上的显著关联(OR=1.33, 95%可信区间,0.85 ~ 2.08,p=0.21)。讨论:总体而言,过去一年中大麻使用与生活质量之间没有显着关联。这可能归因于疼痛是进入该计划的合格条件。
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