Tetsuhiro Harimoto, Wei-Hung Jung, David J. Mooney
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引用次数: 0
Abstract
The engineering of therapeutic living cells through genetic programming is poised to transform medicine. Diverse living medicines, including mammalian cells, fungi, bacteria and viruses, are under development. However, for these medicines to progress in the clinic, new strategies are needed to successfully deliver them into the body. Unlike conventional small-molecule and protein-based biologics, living medicines present distinct challenges for delivery, including the need to maintain viability, control replication, manage metabolism and mitigate immunogenicity. This Review focuses on delivery strategies for living medicines, identifying key challenges and efforts to overcome them. We survey clinically adopted biomaterial strategies for delivering conventional drugs and explore how these approaches can be tailored for living medicines. Finally, we discuss remaining challenges and future directions towards next-generation living medicine delivery. As the field of engineered therapeutic living cells advances, new strategies to deliver them into the body are needed. This Review identifies current challenges in living medicine delivery and discusses how biomaterial strategies could be leveraged to overcome these clinical barriers.
期刊介绍：
Nature Reviews Materials is an online-only journal that is published weekly. It covers a wide range of scientific disciplines within materials science. The journal includes Reviews, Perspectives, and Comments.
Nature Reviews Materials focuses on various aspects of materials science, including the making, measuring, modelling, and manufacturing of materials. It examines the entire process of materials science, from laboratory discovery to the development of functional devices.
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