rTMS improves cognitive function and its real-time and cumulative effect on neuronal excitability in aged mice

IF 2.6 4区医学 Q3 NEUROSCIENCES Brain Research Pub Date : 2025-01-25 DOI:10.1016/j.brainres.2025.149474

Chong Ding , Xueting Pan , Rui Fu , Haoyu Qiu , Haijun Zhu

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is acknowledged for its critical role in modulating neuronal excitability and enhancing cognitive function. The dentate gyrus of the hippocampus is closely linked to cognitive processes; however, the precise mechanisms by which changes in its excitability influence cognition are not yet fully understood. This study aimed to elucidate the effects on granule cell excitability and the effects on cognition of high-frequency rTMS in naturally aging mice, as well as to investigate the potential interactions between these two factors. It was observed that 20 Hz high-frequency rTMS attenuated granule cell loss in aged mice, demonstrating both cumulative and real-time effects on neural excitability. Importantly, this intervention significantly ameliorated age-related cognitive decline. The findings suggest that one of the potential mechanisms underlying the amelioration of age-related cognitive decline through high-frequency rTMS may involve the attenuation of granule cell apoptosis and the enhancement of their neural excitability.

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rTMS改善老年小鼠认知功能及其对神经元兴奋性的实时和累积效应。

重复经颅磁刺激（rTMS）在调节神经元兴奋性和增强认知功能方面具有重要作用。海马体的齿状回与认知过程密切相关；然而，其兴奋性变化影响认知的确切机制尚不完全清楚。本研究旨在阐明高频rTMS对自然衰老小鼠颗粒细胞兴奋性的影响和对认知的影响，并探讨两者之间可能的相互作用。我们观察到，20 Hz高频rTMS可减轻老年小鼠颗粒细胞的损失，显示出对神经兴奋性的累积和实时影响。重要的是，这种干预显著改善了与年龄相关的认知衰退。研究结果表明，高频rTMS改善年龄相关性认知衰退的潜在机制之一可能涉及颗粒细胞凋亡的衰减和神经兴奋性的增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.