Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients.

IF 1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2025-02-01 Epub Date: 2025-01-28 DOI:10.1080/14796678.2025.2458414

Hamideh Khesali, Amir Ghaffari Jolfayi, Amirali Soheili, Parinaz Rezapour, Sara Adimi, Toktam Alirezaei

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Abstract

Introduction: Decreased left atrial appendage emptying velocity (LAAV) is a marker for thrombus formation. This study evaluates the association between LAAV and inflammatory indices in non-valvular atrial fibrillation (AF) patients.

Methods: The study population was 1428 patients with AF, 875 of whom enrolled. Based on the LAAV, patients were divided into three groups of 262 patients with a velocity of <25 cm/s, 360 patients with a velocity of 25 to 55 cm/s, and 253 patients with a velocity of >55 cm/s to assess and compare in terms of inflammatory indices, including the platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune inflammation index, neutrophil - to - platelet ratio and white blood cell-to-platelet ratio (WPR).

Results: There was no statistical difference in the level of inflammatory indices between the three groups, and none of them were related to LAAV (p > .05) except WPR with a weak negative correlation (p = 0.01, r = -0.10). Patients with lower LAAV were found to have a higher age (p = 0.001), decreased left ventricular ejection fraction (p = 0.001) and greater left atrial volume index (p = 0.001).

Conclusion: This study did not show any association between inflammatory indices and LAAV in non-valvular AF patients except for the WPR.

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非瓣膜性房颤患者左心耳速度与炎症指标的关系。

左心耳排空速度降低是血栓形成的标志。本研究评估非瓣膜性心房颤动（AF）患者LAAV与炎症指标之间的关系。方法：研究人群为1428例房颤患者，其中875例入组。根据LAAV将患者分为三组，每组262例，流速为55 cm/s，评估和比较炎症指标，包括血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值、全身免疫炎症指数、中性粒细胞与血小板比值、白细胞与血小板比值（WPR）。结果：三组间炎症指标水平差异无统计学意义，除WPR呈弱负相关（p = 0.01, r = -0.10）外，均与LAAV无关（p < 0.05）。LAAV较低的患者年龄较大（p = 0.001），左室射血分数降低（p = 0.001），左房容积指数较大（p = 0.001）。结论：除WPR外，本研究未发现非瓣膜性房颤患者的炎症指标与LAAV有任何关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.