From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography.

IF 4.4 2区 医学 Q1 NEUROSCIENCES Journal of Neuroscience Pub Date : 2025-03-19 DOI:10.1523/JNEUROSCI.1429-24.2025
Nicholas C Cottam, Kwadwo Ofori, Kevin T Stoll, Madison Bryant, Jessica R Rogge, Khan Hekmatyar, Jianli Sun, Christine J Charvet
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Abstract

Animal models are commonly used to investigate developmental processes and disease risk, but humans and model systems (e.g., mice) differ substantially in the pace of development and aging. The timeline of human developmental circuits is well known, but it is unclear how such timelines compare with those in mice. We lack age alignments across the lifespan of mice and humans. Here, we build upon our Translating Time resource, which is a tool that equates corresponding ages during development. We collected 1,125 observations from age-related changes in body, bone, dental, and brain processes to equate corresponding ages across humans, mice, and rats to boost power for comparison across humans and mice. We acquired high-resolution diffusion MR scans of mouse brains (n = 16) of either sex at sequential stages of postnatal development [postnatal day (P)3, 4, 12, 21, 60] to track brain circuit maturation (e.g., olfactory association, transcallosal pathways). We found heterogeneity in white matter pathway growth. Corpus callosum growth largely ceases days after birth, while the olfactory association pathway grows through P60. We found that a P3-4, mouse equates to a human at roughly GW24 and a P60 mouse equates to a human in teenage years. Therefore, white matter pathway maturation is extended in mice as it is in humans, but there are species-specific adaptations. For example, olfactory-related wiring is protracted in mice, which is linked to their reliance on olfaction. Our findings underscore the importance of translational tools to map common and species-specific biological processes from model systems to humans.

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来源期刊
Journal of Neuroscience
Journal of Neuroscience 医学-神经科学
CiteScore
9.30
自引率
3.80%
发文量
1164
审稿时长
12 months
期刊介绍: JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles
期刊最新文献
Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions. Involvement of aSPOC in the Online Updating of Reach-to-Grasp to Mechanical Perturbations of Hand Transport. Scaling of Ventral Hippocampal Activity during Anxiety. From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography. The Representation of Stimulus Features during Stable Fixation and Active Vision.
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