Diffuse Peritoneal Carcinomatosis of Prostate Cancer Unveiled by [89Zr]Zr-PSMA-617 PET/CT.

IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2025-02-01 Epub Date: 2024-11-26 DOI:10.1097/RLU.0000000000005604
Moritz B Bastian, Caroline Burgard, Arne Blickle, Samer Ezziddin, Florian Rosar
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Abstract

Abstract: We report an interesting case of a 64-year-old man with a history of radical prostatectomy for prostate cancer. The patient presented with steady increasing prostate-specific antigen levels, but with negative findings on previous multiple conventional prostate-specific membrane antigen (PSMA) PET/CT (with [68Ga]Ga-PSMA-11) and [18F]FDG PET/CT. A recently introduced PSMA tracer using long-lived 89Zr (half-life 3.3 days), [89Zr]Zr-PSMA-617, was administered in attempt to localize potential local recurrence or metastasis. [89Zr]Zr-PSMA-617 PET/CT clearly revealed diffuse peritoneal carcinomatosis and local recurrence of the prostate cancer, which were unidentified on previous conventional PET/CT scans. This case highly demonstrates the potential of PET imaging with the novel PSMA tracer [89Zr]Zr-PSMA-617.

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[89Zr]Zr-PSMA-617 PET/CT显示前列腺癌弥漫性腹膜癌。
摘要:我们报告一个有趣的病例,64岁的男性前列腺癌根治性前列腺切除术的历史。患者表现为前列腺特异性抗原水平稳步上升,但既往多次常规前列腺特异性膜抗原(PSMA) PET/CT ([68Ga]Ga-PSMA-11)和[18F]FDG PET/CT均阴性。最近推出了一种使用长寿命89Zr(半衰期3.3天)的PSMA示踪剂[89Zr]Zr-PSMA-617,试图定位潜在的局部复发或转移。[89Zr]Zr-PSMA-617 PET/CT清晰显示弥漫性腹膜癌及前列腺癌局部复发,这是以往常规PET/CT扫描未发现的。该病例高度证明了新型PSMA示踪剂[89Zr]Zr-PSMA-617的PET成像潜力。
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来源期刊
Clinical Nuclear Medicine
Clinical Nuclear Medicine 医学-核医学
CiteScore
2.90
自引率
31.10%
发文量
1113
审稿时长
2 months
期刊介绍: Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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