Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-01-29 DOI:10.1007/s00406-024-01946-1

Xinyue Wan, Pengfei Zhang, Yanli Jiang, Guangyao Liu, Laiyang Ma, Jing Zhang, Jun Zhang

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Abstract

Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often share multiple similar symptoms and are highly comorbid; however, the common and distinct brain neuroanatomy of these two diseases are unclear. The current study attempted to identify the overlapping and different gray matter volume (GMV) between AN and OCD. We conducted a voxel-wise meta-analysis of GMV using the latest Seed-based d Mapping with Permutation of Subject Images Toolbox (SDM-PSI) software. Compared to healthy controls, patients with AN showed reduced GMV in supplementary motor areas, median cingulate cortices, the left cerebellum, right Rolandic operculum (RO), right insula, right superior temporal gyrus (STG), and right precuneus, while OCD patients were characterized by low GMV in the right insula, STG, RO, and inferior frontal gyrus (IFG). The conjunctional analysis indicated that these two disorders have overlapping structural abnormalities in the right insula, STG, RO and IFG. No distinct GMV alteration was found. These common structural brain abnormalities may underlie the neuropathology of the similar neuropsychological features and highly comorbid manifestations of AN and OCD.

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神经性厌食症和强迫症患者灰质改变的常见和独特的神经模式。

神经性厌食症（AN）和强迫症（OCD）通常有多种相似的症状，并且高度共病；然而，这两种疾病的共同和独特的脑神经解剖学尚不清楚。本研究试图确定AN和OCD之间的重叠和不同的灰质体积（GMV）。我们使用最新的基于种子的d Mapping with Permutation of Subject Images Toolbox （SDM-PSI）软件对GMV进行了体素方面的meta分析。与健康对照组相比，AN患者在辅助运动区、扣带正中皮层、左小脑、右罗兰包盖（RO）、右岛、右颞上回（STG）和右楔前叶等部位的GMV均降低，而强迫症患者在右岛、STG、RO和额下回（IFG）的GMV均降低。联合分析表明，这两种疾病在右岛、STG、RO和IFG有重叠的结构异常。未发现明显的GMV改变。这些常见的脑结构异常可能是AN和OCD相似的神经心理特征和高度共病表现的神经病理学基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.