Head-to-Head Comparison Between [ 68 Ga]Ga-DOTA.SA.FAPi And [ 18 F]F-FDG PET/CT Imaging in Patients With Sarcoma.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2025-05-01 Epub Date: 2025-01-29 DOI:10.1097/RLU.0000000000005697

Mohammad Sakir, Sanjana Ballal, Sameer Rastogi, Madhav Prasad Yadav, Frank Roesch, Kunal Chandekar, Priyanka Gb, Madhavi Tripathi, Ayan Dhiman, Mehul Taggar, Marcel Martin, Chandrasekhar Bal

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Abstract

Purpose: This study aimed to compare the diagnostic efficacy of [ 68 Ga]Ga-DOTA.SA.FAPi and [ 18 F]F-FDG PET/CT for detecting primary and metastatic lesions in sarcoma patients.

Materials and methods: The analysis included both patient-based and lesion-based comparisons of PET/CT scans in individuals with histologically confirmed sarcoma.

Results: A total of 23 sarcoma patients (mean age 43.0 ± 16.5 years; range: 21-76 years) underwent both [ 18 F]F-FDG and [ 68 Ga]Ga-DOTA.SA.FAPi PET/CT scans. Histological distribution included 30% synovial sarcoma, 13% liposarcoma, and 21.7% leiomyosarcoma, with 70% of patients presenting with distant metastases. Detection rates for primary tumors were similar between [ 68 Ga]Ga-DOTA.SA.FAPi and [ 18 F]F-FDG PET/CT (85.7% vs 100%, P = 0.149). Lymph node detection rates were also comparable (80% vs 100%, P = 0.146). Lesion-based analysis revealed that [ 68 Ga]Ga-DOTA.SA.FAPi detected 220 lesions (83% efficiency) compared with 249 lesions (94% efficiency) for [ 18 F]F-FDG ( P < 0.0001). Notably, [ 68 Ga]Ga-DOTA.SA.FAPi demonstrated superior detection of liver (54 vs 38 lesions, P < 0.0001) and bone metastases (125 vs 102 lesions, P < 0.0001).

Conclusions: Our study shows that although [ 18 F]F-FDG PET/CT offers superior overall lesion detection efficiency, [ 68 Ga]Ga-DOTA.SA.FAPi PET/CT excels in identifying specific metastatic sites, particularly in bone and liver. These findings highlight the complementary roles of both imaging modalities in sarcoma evaluation.

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[68Ga]Ga-DOTA.SA。FAPi和[18F]F-FDG在肉瘤患者PET/CT成像中的应用。

目的：比较[68Ga]Ga-DOTA.SA的诊断效果。FAPi和[18F]F-FDG PET/CT对肉瘤患者原发性和转移性病变的检测。材料和方法：该分析包括对组织学证实的肉瘤患者的PET/CT扫描进行基于患者和基于病变的比较。结果：共23例肉瘤患者(平均年龄43.0±16.5岁；年龄范围：21 ~ 76岁)同时接受了[18F]F-FDG和[68Ga]Ga-DOTA.SA。FAPi PET/CT扫描。组织学分布包括30%滑膜肉瘤、13%脂肪肉瘤和21.7%平滑肌肉瘤，70%的患者表现为远处转移。[68Ga]Ga-DOTA.SA的原发肿瘤检出率相似。FAPi和[18F]F-FDG PET/CT （85.7% vs 100%, P = 0.149）。淋巴结检出率也具有可比性（80% vs 100%, P = 0.146）。基于病变的分析显示[68Ga]Ga-DOTA.SA。FAPi检测到220个病变（83%的效率），而[18F]F-FDG检测到249个病变（94%的效率）（P < 0.0001）。值得注意的是,ga [68] Ga-DOTA.SA。FAPi对肝脏（54 vs 38, P < 0.0001）和骨转移（125 vs 102, P < 0.0001）的检测效果更好。结论：我们的研究表明，尽管[18F]F-FDG PET/CT具有更好的整体病变检测效率，但[68Ga]Ga-DOTA.SA。FAPi PET/CT擅长识别特定的转移部位，特别是在骨和肝脏。这些发现强调了两种成像方式在肉瘤评估中的互补作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.