{"title":"Arechuines A-D, arecoline alkaloids from the peels of <i>Areca catechu</i> L.","authors":"Biao Sun, Yuanning Wu, Jianzhan Yang, Shiqing Zhang, Fangfang Xu, Xiaoqi Zhang","doi":"10.1080/14786419.2025.2455460","DOIUrl":null,"url":null,"abstract":"<p><p>Four novel arecoline alkaloid atropisomers, arechuines A-D (<b>1 </b>-<b> 4</b>), were obtained from the peels of <i>Areca catechu</i> L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)-<b>4</b> were determined by comparing the experimental and calculated ECD spectra. Compounds <b>1 </b>-<b> 4</b> were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and <b>3</b> revealed potent neuroprotective effects at 10 μM. These are the first reported arecoline alkaloid atropisomers isolated from <i>A. catechu.</i></p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2455460","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Four novel arecoline alkaloid atropisomers, arechuines A-D (1 - 4), were obtained from the peels of Areca catechu L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)-4 were determined by comparing the experimental and calculated ECD spectra. Compounds 1 - 4 were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and 3 revealed potent neuroprotective effects at 10 μM. These are the first reported arecoline alkaloid atropisomers isolated from A. catechu.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
