Andreas Boldt, Regina Treudler, Marie Rabe, Niklas Artz, Sabine Seiffert, Rachael Bogle, Xianying Xing, Louise Wilkens, Ariane Bialas, Lea Präger, Lam C Tsoi, Ulrike Koehl, Sandra Franz, Sonja Grunewald, Jan C Simon, J Michelle Kahlenberg, Johann E Gudjonsson, Benjamin Klein
{"title":"Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis.","authors":"Andreas Boldt, Regina Treudler, Marie Rabe, Niklas Artz, Sabine Seiffert, Rachael Bogle, Xianying Xing, Louise Wilkens, Ariane Bialas, Lea Präger, Lam C Tsoi, Ulrike Koehl, Sandra Franz, Sonja Grunewald, Jan C Simon, J Michelle Kahlenberg, Johann E Gudjonsson, Benjamin Klein","doi":"10.1111/all.16492","DOIUrl":null,"url":null,"abstract":"<p><p>We assessed STAT activation in T cells in blood and skin of AD patients versus HC. pSTAT5<sup>+</sup> T cells were increased in AD blood, correlated with disease activity, and were induced by common γc cytokines. Skin T cells exhibited a STAT6 signature, whereas only a subset was positive for STAT5. AD, atopic dermatitis; HC, healthy controls; STAT: Signal Transducers and Activators of Transcription.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/all.16492","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
We assessed STAT activation in T cells in blood and skin of AD patients versus HC. pSTAT5+ T cells were increased in AD blood, correlated with disease activity, and were induced by common γc cytokines. Skin T cells exhibited a STAT6 signature, whereas only a subset was positive for STAT5. AD, atopic dermatitis; HC, healthy controls; STAT: Signal Transducers and Activators of Transcription.
期刊介绍：
Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality.
Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
