D. Do, L. Bertolotti, A. Mosnier, A. Facile, V. Bourdenet, N. Poletto, A. Guironnet‐Paquet, F. Hacard, A. Nosbaum, F. Bérard, J.‐F. Nicolas, M. Vocanson, M.‐A. Lefevre, M. Tauber
{"title":"Allergic Signature in Delayed Cross‐Hypersensitivity to all Iodinated Contrast Media","authors":"D. Do, L. Bertolotti, A. Mosnier, A. Facile, V. Bourdenet, N. Poletto, A. Guironnet‐Paquet, F. Hacard, A. Nosbaum, F. Bérard, J.‐F. Nicolas, M. Vocanson, M.‐A. Lefevre, M. Tauber","doi":"10.1111/all.16533","DOIUrl":"https://doi.org/10.1111/all.16533","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"70 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correspondence: Causal Associations Between Chronic Spontaneous Urticaria and Thyroid Function Indicators in Different Ethnic Groups: A Bidirectional Two-Sample Mendelian Randomization Analysis.","authors":"Youqian Zhang, Jiejun Zhou, Yao Ni","doi":"10.1111/all.16531","DOIUrl":"https://doi.org/10.1111/all.16531","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Arzt‐Gradwohl, Urban Čerpes, Eva Schadelbauer, Clemes Schöffl, Sereina Annik Herzog, Christoph Schrautzer, Danijela Bokanovic, Lukas Koch, Karin Laipold, Barbara Binder, Gunter Sturm
{"title":"A Safe and Efficient 7‐Week Immunotherapy Protocol With Aluminum Hydroxide Adsorbed Bee Venom","authors":"Lisa Arzt‐Gradwohl, Urban Čerpes, Eva Schadelbauer, Clemes Schöffl, Sereina Annik Herzog, Christoph Schrautzer, Danijela Bokanovic, Lukas Koch, Karin Laipold, Barbara Binder, Gunter Sturm","doi":"10.1111/all.16528","DOIUrl":"https://doi.org/10.1111/all.16528","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"183 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadia Baalbaki, Elise M A Slob, Samuel W Kazer, Mahmoud I Abdel-Aziz, Harm Jan Bogaard, Korneliusz Golebski, Anke H Maitland-van der Zee
An estimated 10% of coronavirus disease (COVID-19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD42024499281) aimed to explore the pathophysiological mechanisms underlying LC and potential treatable traits across symptom-based phenotypes. We included studies with primary data, written in English, focusing on omics analyses of human samples from LC patients with persistent symptoms of at least 3 months. Our search in PubMed and Embase, conducted on January 8, 2024, identified 642 studies, of which 29 met the inclusion criteria after full-text assessment. The risk of bias was evaluated using the Joanna Briggs Institute appraisal tool. The synthesis of omics data, including genomics, transcriptomics, proteomics, metabolomics, and metagenomics, revealed common findings associated with fatigue, cardiovascular, pulmonary, neurological, and gastrointestinal phenotypes. Key findings included mitochondrial dysfunction, dysregulated microRNAs associated with pulmonary dysfunction, tissue impairment, blood-brain barrier disruption, coagulopathy, vascular dysfunction, microbiome disturbances, microbial-derived metabolite production and persistent inflammation. Limitations include cross-study heterogeneity and variability in sampling methods. Our review emphasizes the complexity of LC and the need for further longitudinal omics-integrated studies to advance the development of biomarkers and targeted treatments.
{"title":"The Omics Landscape of Long COVID-A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery.","authors":"Nadia Baalbaki, Elise M A Slob, Samuel W Kazer, Mahmoud I Abdel-Aziz, Harm Jan Bogaard, Korneliusz Golebski, Anke H Maitland-van der Zee","doi":"10.1111/all.16526","DOIUrl":"https://doi.org/10.1111/all.16526","url":null,"abstract":"<p><p>An estimated 10% of coronavirus disease (COVID-19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD42024499281) aimed to explore the pathophysiological mechanisms underlying LC and potential treatable traits across symptom-based phenotypes. We included studies with primary data, written in English, focusing on omics analyses of human samples from LC patients with persistent symptoms of at least 3 months. Our search in PubMed and Embase, conducted on January 8, 2024, identified 642 studies, of which 29 met the inclusion criteria after full-text assessment. The risk of bias was evaluated using the Joanna Briggs Institute appraisal tool. The synthesis of omics data, including genomics, transcriptomics, proteomics, metabolomics, and metagenomics, revealed common findings associated with fatigue, cardiovascular, pulmonary, neurological, and gastrointestinal phenotypes. Key findings included mitochondrial dysfunction, dysregulated microRNAs associated with pulmonary dysfunction, tissue impairment, blood-brain barrier disruption, coagulopathy, vascular dysfunction, microbiome disturbances, microbial-derived metabolite production and persistent inflammation. Limitations include cross-study heterogeneity and variability in sampling methods. Our review emphasizes the complexity of LC and the need for further longitudinal omics-integrated studies to advance the development of biomarkers and targeted treatments.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piotr Brzoza, Michelle Camacho, Mariia Tyshchenko, Agnieszka Morytko, Mateusz Kwitniewski, Maciej Pastuszczak, Paulina Stepinska, Marcin Migaczewski, Joanna Cichy
{"title":"3D Model of Human Epidermis Exposed to Staphylococci Reveals Keratinocyte Responses Unique to Atopy-Associated S. aureus Challenge.","authors":"Piotr Brzoza, Michelle Camacho, Mariia Tyshchenko, Agnieszka Morytko, Mateusz Kwitniewski, Maciej Pastuszczak, Paulina Stepinska, Marcin Migaczewski, Joanna Cichy","doi":"10.1111/all.16524","DOIUrl":"https://doi.org/10.1111/all.16524","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Teresa Bilotta, Paola Vacca, Mariacristina Esposito, Luca Buzzonetti, Giuseppe Bianco, Alessandro Giovanni Fiocchi, Lorenzo Moretta, Massimiliano Raponi, Maria Cristina Artesani, Nicola Tumino
{"title":"Immunophenotyping in Vernal Keratoconjunctivitis: Schirmer Test for Therapy Response Prediction.","authors":"Maria Teresa Bilotta, Paola Vacca, Mariacristina Esposito, Luca Buzzonetti, Giuseppe Bianco, Alessandro Giovanni Fiocchi, Lorenzo Moretta, Massimiliano Raponi, Maria Cristina Artesani, Nicola Tumino","doi":"10.1111/all.16525","DOIUrl":"https://doi.org/10.1111/all.16525","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correspondence to “The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper”","authors":"Umberto Semenzato, Daniele Previtero, Ylenia Padrin, Simonetta Baraldo, Mariaenrica Tinè","doi":"10.1111/all.16523","DOIUrl":"https://doi.org/10.1111/all.16523","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"68 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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