Brittany M. Klootwyk, Grace M. Fleury, Savannah Albright, Alexander Deiters and Paul E. Floreancig
{"title":"Difunctional oxidatively cleavable alkenyl boronates: application to cellular peroxide sensing from a fluorophore–quencher pair†","authors":"Brittany M. Klootwyk, Grace M. Fleury, Savannah Albright, Alexander Deiters and Paul E. Floreancig","doi":"10.1039/D5CC00090D","DOIUrl":null,"url":null,"abstract":"<p >This manuscript describes the development of difunctional alkenyl boronates that contain an oxidatively releasable cargo and an amine for attaching to groups that can improve physical properties or enhance cellular targeting. The design is applied to a FRET-based system that delivers a selective fluorescence response in oxidatively stressed cells.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" 16","pages":" 3375-3378"},"PeriodicalIF":4.2000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784462/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc00090d","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This manuscript describes the development of difunctional alkenyl boronates that contain an oxidatively releasable cargo and an amine for attaching to groups that can improve physical properties or enhance cellular targeting. The design is applied to a FRET-based system that delivers a selective fluorescence response in oxidatively stressed cells.
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