Critical Review of Ketogenic Diet Throughout the Cancer Continuum for Neuroglioma: Insights from a Medical Nutrition Therapy (MNT) Perspective.

IF 5.5 3区医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2025-01-30 DOI:10.1007/s13668-025-00609-4

Kristina D Thomopoulos-Titomihelakis, Hillary Sachs, Rayna McCann, Qianhui Zhang, Sydney Kurnit, Genesis Codoni De Juan, Amanda Rushing

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Abstract

PURPOSE OF REVIEW: A Ketogenic diet (KD; a diet comprised of 75% fat, 20% protein and 5% carbohydrates) has gained much popularity in recent years, especially regarding neurogliomas (or "gliomas"). This review critically assesses literature on the application of KD throughout the cancer continuum from a Medical Nutrition Therapy (MNT) perspective. RECENT FINDINGS: 2021 revised classification standards for Central Nervous System (CNS) tumors are available. Despite research on KD and CNS tumors increasing, the role and benefits of MNT to augment side effects of traditional treatment and KD throughout the cancer continuum remain unclear. Glioma cancer survivors may benefit from a KD. It is a challenging, yet feasible non-pharmacological adjuvant approach. More research is needed regarding KD for prevention and post-treatment of glioma. Standard guidelines regarding macronutrient composition of KD for glioma are warranted. The need and benefits of nutritional guidance provided by a Registered Dietitian Nutritionist (RD or RDNs) during adherence to KD are understated.

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生酮饮食在神经胶质瘤癌症连续体中的重要回顾：从医学营养治疗（MNT）角度的见解。

综述的目的：生酮饮食(KD；近年来，由75%脂肪、20%蛋白质和5%碳水化合物组成的饮食越来越受欢迎，特别是对于神经胶质瘤（或“神经胶质瘤”）。这篇综述从医学营养治疗（MNT）的角度批判性地评估了KD在整个癌症连续体中的应用。最新发现：2021年修订的中枢神经系统（CNS）肿瘤分类标准可用。尽管对KD和CNS肿瘤的研究越来越多，但MNT在整个癌症连续体中增加传统治疗和KD副作用的作用和益处仍不清楚。神经胶质瘤幸存者可能受益于KD。这是一种具有挑战性但可行的非药物辅助方法。KD在胶质瘤的预防和后处理方面还需要更多的研究。关于脑胶质瘤KD的常量营养素组成的标准指南是必要的。注册营养师（RD或rdn）在坚持KD期间提供营养指导的必要性和益处被低估了。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.