Arnaldo Fim Neto , Fabio Godinho , Luiz Ricardo Trajano da Silva , Julia Baldi de Luccas , André Kazuo Takahata , Eberval Gadelha Figueiredo , Carlos Gilberto Carlotti Junior , Maria Sheila Guimarães Rocha , Diogo Coutinho Soriano
{"title":"Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson’s disease","authors":"Arnaldo Fim Neto , Fabio Godinho , Luiz Ricardo Trajano da Silva , Julia Baldi de Luccas , André Kazuo Takahata , Eberval Gadelha Figueiredo , Carlos Gilberto Carlotti Junior , Maria Sheila Guimarães Rocha , Diogo Coutinho Soriano","doi":"10.1016/j.clinph.2025.01.005","DOIUrl":null,"url":null,"abstract":"<div><div><strong>Introduction:</strong> Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson’s disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP). <strong>Methods:</strong> The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG). <strong>Results:</strong> FOG patients presented enhanced alpha bandpower (FOG <em>vs</em>. n-FOG: 0.331 ± 0.087 <em>vs</em>. 0.248 ± 0.089; p = 0.011) and intermittent (burst) alpha amplitude (FOG <em>vs</em>. n-FOG: 0.610 ± 0.068 <em>vs</em>. 0.524 ± 0.086; p = 0.005). Both intermittent alpha (r = 0.330, p = 0.046) and intermittent high beta amplitude (r = 0.415, p = 0.011) correlated with the FOG score. Alpha burst amplitude correlated with FOG severity (r = 0.479, p = 0.003), and high beta burst amplitude inversely correlated (r = −0.411, p = 0.014) with the performance-oriented mobility assessment (POMA) index. <strong>Conclusion:</strong> These results suggest that alpha and high beta subthalamic oscillations impact FOG symptoms. <strong>Significance:</strong> The investigation suggests potentially newer co-biomarkers of FOG to guide multi-rhythm paradigms in DBS treatment.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 51-60"},"PeriodicalIF":3.6000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138824572500015X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson’s disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP). Methods: The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG). Results: FOG patients presented enhanced alpha bandpower (FOG vs. n-FOG: 0.331 ± 0.087 vs. 0.248 ± 0.089; p = 0.011) and intermittent (burst) alpha amplitude (FOG vs. n-FOG: 0.610 ± 0.068 vs. 0.524 ± 0.086; p = 0.005). Both intermittent alpha (r = 0.330, p = 0.046) and intermittent high beta amplitude (r = 0.415, p = 0.011) correlated with the FOG score. Alpha burst amplitude correlated with FOG severity (r = 0.479, p = 0.003), and high beta burst amplitude inversely correlated (r = −0.411, p = 0.014) with the performance-oriented mobility assessment (POMA) index. Conclusion: These results suggest that alpha and high beta subthalamic oscillations impact FOG symptoms. Significance: The investigation suggests potentially newer co-biomarkers of FOG to guide multi-rhythm paradigms in DBS treatment.
步态冻结（FOG）是一种致残症状，影响了超过一半的帕金森病患者（PD），阻碍了他们的行走能力。由于缺乏来自局部场电位（LFP）的可靠电生理生物标志物，丘脑下核（STN）深部脑刺激（DBS）在改善FOG方面的有效性仍存在争议。方法：对23例患者（14例有FOG， 9例无FOG）进行静息时LFP-STN节律带功率和动态特征分析。结果：FOG患者α带功率增强(FOG vs. n-FOG: 0.331±0.087 vs. 0.248±0.089；p = 0.011)和间歇性（突发）α振幅(FOG vs. n-FOG: 0.610±0.068 vs. 0.524±0.086；p = 0.005)。间歇α (r = 0.330, p = 0.046)和间歇高β振幅（r = 0.415, p = 0.011）均与FOG评分相关。α突发幅值与FOG严重程度呈负相关（r = 0.479, p = 0.003），高β突发幅值与绩效导向流动性评估（POMA）指数呈负相关（r = -0.411, p = 0.014）。结论：这些结果表明α和高β丘脑底振荡影响FOG症状。意义：该研究提示可能有更新的FOG共同生物标志物来指导DBS治疗中的多节律范式。
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
