Assessing the Correlation Between Langerhans Cells Population and Prognosis of Tongue Squamous Cell Carcinoma

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2025-01-30 DOI:10.1002/cre2.70080

Narges Ghazi, Nasrollah Saghravanian, Pooya Saeedi, Mohammad Mahdi Maboudinezhad

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Abstract

Background and Objective

Tongue squamous cell carcinoma (TSCC) is the most prevalent oral cancer. Despite considerable advancements in treatment, the 5-year survival rate remains relatively unchanged. Langerhans cells (LCs) play an important role in antitumor immunity. Therefore, we attempt to evaluate the correlation between the LC count and disease prognosis.

Materials and Methods

Histopathologic slides from 24 cases, with at least 2 years of follow-up, were selected and categorized into early-stage (12 cases) and advanced-stage (12 cases) groups. An additional 12 slides of normal tissue comprised the control group. Immunohistochemical staining with the CD1a marker was performed to analyze the density of LCs. Statistical analysis assessed the impact of CD1a immune expression on patient survival and other variables such as age, gender, stage, and histopathological grade.

Results

Comparison of CD1a+ cell counts across the three groups revealed a significant decrease in the advanced group. Furthermore, a lower count of CD1a+ cells correlated with poorer disease-free survival (DFS) (p < 0.001) and overall survival (OS) (p = 0.049). Although the CD1a+ cell count did not independently affect OS significantly (p = 0.210), it did show a significant impact on DFS as an independent variable (p = 0.002).

Conclusion

The significant correlation between CD1a expression and patients' prognosis and survival rates suggests that CD1a+ cells could serve as a crucial prognostic factor in the management and treatment of TSCC.

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舌鳞癌朗格汉斯细胞群与预后的相关性研究。

背景与目的：舌鳞状细胞癌是最常见的口腔癌。尽管治疗取得了相当大的进步，但5年生存率仍然相对不变。朗格汉斯细胞（LCs）在抗肿瘤免疫中起重要作用。因此，我们试图评估LC计数与疾病预后的相关性。材料与方法：选取24例随访2年以上的组织病理切片，分为早期组（12例）和晚期组（12例）。另外12片正常组织作为对照组。采用CD1a标记免疫组化染色分析细胞密度。统计分析评估了CD1a免疫表达对患者生存和其他变量（如年龄、性别、分期和组织病理学分级）的影响。结果：三组CD1a+细胞计数比较显示，晚期组CD1a+细胞计数明显下降。结论：CD1a表达与患者预后和生存率之间的显著相关性表明，CD1a+细胞在TSCC的管理和治疗中可能是一个至关重要的预后因素。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.