A new steroid from Penicillium brocae G2131.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI:10.1080/10286020.2025.2451332

Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang

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Abstract

A comprehensive study was carried out on Penicillium brocae G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (1), four known compounds: demethylincisterol A₃ (2), (22E, 24 R)-ergosta-7,9(11),22-trien-3β-ol (3), (22E,24R)-5α,8α-epidixyer-gosta-6,22-dien-3β-ol (4) and p- hydroxybenzaldehyde (5). The structure of compound 1 was determined using a variety of spectroscopic methods such as ¹H spectrum,¹³C spectrum, HMBC, HSQC,¹H-¹H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound 1 was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.

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从西兰花青霉菌G2131中分离出一个新的甾体。

对源自云南勐海普洱茶的brocae青霉G2131进行了综合研究。本研究共鉴定出5个化合物，其中一个是新发现的化合物：(5aR)-6-（(2R,5R，E)-5,6-二甲基庚-3-烯-2-基）-5a-甲基-5,5a,6,7,8,8 - a-六氢- 2h -吲哚[5,4-b]呋喃-2-酮(1)，4个已知化合物：去甲基林甾醇A3(2)、(22E,24R)-麦角-7,9（11）、22-三烯-3β-醇(3)、(22E,24R)-5α、8α-附枝-gosta-6,22-二烯-3β-醇(4)和对羟基苯甲醛(5)。采用1H谱、13C谱、HMBC、HSQC、1H-1H COSY、LC-MS、UV、IR等多种波谱方法对化合物1的结构进行了测定，并与文献进行了NMR数据对比。通过对比实验光谱和ECD光谱，确定了化合物1的绝对构型。对所有化合物进行了抗乙酰胆碱活性测试，但均未显示出任何抗乙酰胆碱活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.