A new steroid from Penicillium brocae G2131.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI:10.1080/10286020.2025.2451332

Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang

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引用次数: 0

Abstract

A comprehensive study was carried out on Penicillium brocae G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (1), four known compounds: demethylincisterol A₃ (2), (22E, 24 R)-ergosta-7,9(11),22-trien-3β-ol (3), (22E,24R)-5α,8α-epidixyer-gosta-6,22-dien-3β-ol (4) and p- hydroxybenzaldehyde (5). The structure of compound 1 was determined using a variety of spectroscopic methods such as ¹H spectrum,¹³C spectrum, HMBC, HSQC,¹H-¹H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound 1 was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.