{"title":"Two new amino acid-derived oximes from the mangrove-sediment-derived fungus Lecanicillium kalimantanense SCSIO 41702","authors":"Xu-Meng Ren , Lin-Fang Zhong , Ke-Yue Wu , Xiao Liang , Shu-Hua Qi","doi":"10.1080/14786419.2025.2459816","DOIUrl":null,"url":null,"abstract":"<div><div>Two new amino acid-derived oximes <em>N</em>-(2-hydroxyimino-4-methylpentanoyl)-<em>L</em>-isoleucine (<strong>1</strong>) and <em>N</em>-(2-hydroxyimino-4-methylpentanoyl)-<em>L</em>-leucine (<strong>2</strong>), along with two known analogues (<em>E</em>)-<em>N</em>-(2-hydroxyimino-3-phenylpropanoyl)-<em>L</em>-phenylalanine (<strong>3</strong>) and methyl (<em>E</em>)-<em>N</em>- (2-hydroxyimino-3-phenylpropanoyl)-<em>L</em>-phenylalaninate (<strong>4</strong>), were isolated from the mangrove-sediment-derived fungus <em>Lecanicillium kalimantanense</em> SCSIO 41702. Their structures were determined by spectroscopic analysis. The absolute configurations of <strong>1</strong> and <strong>2</strong> were determined by Marfey’s method. Compounds <strong>1</strong> and <strong>2</strong> showed medium inhibitory activity against LPS-induced NO production.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 2","pages":"Pages 581-588"},"PeriodicalIF":1.6000,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641925000464","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Two new amino acid-derived oximes N-(2-hydroxyimino-4-methylpentanoyl)-L-isoleucine (1) and N-(2-hydroxyimino-4-methylpentanoyl)-L-leucine (2), along with two known analogues (E)-N-(2-hydroxyimino-3-phenylpropanoyl)-L-phenylalanine (3) and methyl (E)-N- (2-hydroxyimino-3-phenylpropanoyl)-L-phenylalaninate (4), were isolated from the mangrove-sediment-derived fungus Lecanicillium kalimantanense SCSIO 41702. Their structures were determined by spectroscopic analysis. The absolute configurations of 1 and 2 were determined by Marfey’s method. Compounds 1 and 2 showed medium inhibitory activity against LPS-induced NO production.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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