Lobopaucinoids A-Q, bioactive terpenoids from the soft coral Lobophytum pauciflorum collected in the South China Sea

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Phytochemistry Pub Date : 2025-01-28 DOI:10.1016/j.phytochem.2025.114416

Xiao Han , Di Zhang , Xiaolei Li , Xiaobin Li , Xuli Tang , Guoqiang Li

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Abstract

Two undescribed rearranged diterpenoids, lobopaucinoids A and B (1 and 2), along with thirteen undescribed lobane-type diterpenoids lobopaucinoids C–O (3–15) including a C₁₈ (11) and two C₁₇ (12 and 13) undescribed norditerpenoids, were isolated from the soft coral Lobophytum pauciflorum Ehrenberg (Sarcophytidae family) collected from Xisha Islands of the South China Sea. Additionally, two undescribed prenyleudesmane-type diterpenoids, lobopaucinoids P and Q (16 and 17), as well as two known lobane diterpenoids (18 and 19), were also obtained. Their structures were elucidated based on comprehensive spectroscopic data, Mosher's method, Mo₂(OAc)₄ or Rh₂(OCOCF₃)₄-induced circular dichroism experiment, quantum chemical calculations, and single-crystal X-ray diffraction and literature comparison. Biological evaluation indicated that compounds 3, 4 and 15 exhibited weak anti-inflammatory activities with the rates from 24.34 % to 35.13 % at the concentration of 20 μM. In addition, compound 1 showed significant hepatoprotective activity in zebrafish model.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.

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