Global prevalence of fatigue in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Respiratory medicine Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI:10.1016/j.rmed.2025.107969

Wenting Shi , Tao Li , Yingjie Leng , Qinglu Li , Nan Wang , Guorong Wang

{"title":"Global prevalence of fatigue in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis","authors":"Wenting Shi , Tao Li , Yingjie Leng , Qinglu Li , Nan Wang , Guorong Wang","doi":"10.1016/j.rmed.2025.107969","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Fatigue is a common symptom in patients with chronic obstructive pulmonary disease (COPD). Published studies of fatigue among patients with COPD have presented diverse findings that may reflect variations in research methods as well as actual population differences.</div></div><div><h3>Objective</h3><div>To estimate the worldwide prevalence of fatigue in patients with COPD and its associated epidemiological characteristics.</div></div><div><h3>Methods</h3><div>The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and China Biology Medicine disc (CBM) databases were searched for articles from their inception date through August 2024. The pooled prevalence of fatigue in patients with COPD and 95 % confidence interval (CI) were calculated using a random-effects model with Stata 15.0 software. Agency for Healthcare and Research and Quality (AHRQ) indicators and the Newcastle-Ottawa Scale (NOS) were used to evaluate the quality of the included studies.</div></div><div><h3>Results</h3><div>The 25 included studies involved 6830 patients. The meta-analysis results showed a 59 % (95 % CI: 52%–66 %) pooled prevalence of fatigue in patients with COPD. Subgroup analysis indicated that the prevalence varied significantly by region, setting, assessment tool, and publication year.</div></div><div><h3>Conclusions</h3><div>Fatigue is a common symptom among patients with COPD worldwide. To reduce the negative effects of fatigue in these patients, clinicians should actively explore the mechanisms of fatigue occurrence and its risk factors to provide a basis for further research.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"238 ","pages":"Article 107969"},"PeriodicalIF":3.1000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0954611125000319","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Fatigue is a common symptom in patients with chronic obstructive pulmonary disease (COPD). Published studies of fatigue among patients with COPD have presented diverse findings that may reflect variations in research methods as well as actual population differences.

Objective

To estimate the worldwide prevalence of fatigue in patients with COPD and its associated epidemiological characteristics.

Methods

The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and China Biology Medicine disc (CBM) databases were searched for articles from their inception date through August 2024. The pooled prevalence of fatigue in patients with COPD and 95 % confidence interval (CI) were calculated using a random-effects model with Stata 15.0 software. Agency for Healthcare and Research and Quality (AHRQ) indicators and the Newcastle-Ottawa Scale (NOS) were used to evaluate the quality of the included studies.

Results

The 25 included studies involved 6830 patients. The meta-analysis results showed a 59 % (95 % CI: 52%–66 %) pooled prevalence of fatigue in patients with COPD. Subgroup analysis indicated that the prevalence varied significantly by region, setting, assessment tool, and publication year.

Conclusions

Fatigue is a common symptom among patients with COPD worldwide. To reduce the negative effects of fatigue in these patients, clinicians should actively explore the mechanisms of fatigue occurrence and its risk factors to provide a basis for further research.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

慢性阻塞性肺疾病患者疲劳的全球患病率：系统回顾和荟萃分析

背景：疲劳是慢性阻塞性肺疾病（COPD）患者的常见症状。已发表的关于慢性阻塞性肺病患者疲劳的研究提出了不同的发现，这可能反映了研究方法的差异以及实际的人群差异。目的：估计慢性阻塞性肺病患者疲劳的全球患病率及其相关的流行病学特征。方法：检索Cochrane图书馆、护理与相关健康文献累积索引（CINAHL）、PubMed、Web of Science、Embase、中国知网（CNKI）、万方数据库、中国科技期刊数据库（VIP）和中国生物医学光盘（CBM）数据库自建库之日起至2024年8月的文章。使用Stata 15.0软件的随机效应模型计算COPD患者疲劳的总患病率和95%置信区间（CI）。采用卫生保健和研究质量机构（AHRQ）指标和纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。结果：纳入的25项研究涉及6830例患者。荟萃分析结果显示，COPD患者中疲劳的总患病率为59% （95% CI: 52%-66%）。亚组分析表明，患病率因地区、环境、评估工具和出版年份而有显著差异。结论：疲劳是全球COPD患者的常见症状。为减少疲劳对该类患者的负面影响，临床医生应积极探索疲劳发生的机制及其危险因素，为进一步研究提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.