A tale of two tissues: Patterning of the epidermis through morphogens and their role in establishing tracheal system organization

Abstract

Throughout embryonic development, cells respond to a diverse set of signals and forces, making individual or collective decisions that drive the formation of specialized tissues. The development of these structures is tightly regulated in space and time. In recent years, the possibility that neighboring tissues influence one another's morphogenesis has been explored, as some of them develop simultaneously. We study this issue by reviewing the interactions between Drosophila epidermal and tracheal tissues in early and late stages of embryogenesis. Early in development, the epidermis emerges from the ectodermal layer. During its differentiation, epidermal cells produce morphogen gradients that influence the fundamental organization of the embryo. In this work, we analyze how molecules produced by the epidermis guide tracheal system development. Since both tissues emerge from the same germ layer and lie in close proximity all along their development, they are an excellent model for studying induction processes and tissue interactions.