Silk-based biomaterials for tissue engineering

IF 19.3 1区 化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2025-01-27 DOI:10.1016/j.cis.2025.103413
Ting Zhang , Rui Zhang , Yunyang Zhang , Perumal Ramesh Kannan , Yao Li , Yudie Lv , Ruibo Zhao , Xiangdong Kong
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Abstract

Tissue engineering (TE) involves repairing, replacing, regeneration, or improving the function of tissues and organs by combining cells, growth factors and scaffold materials. Among these, scaffold materials play a crucial role. Silk fibroin (SF), a natural biopolymer, has been widely used in the TE field due to its good biodegradability, biocompatibility, and mechanical properties attributed to its chemical composition and structure. This paper reviews the structure, extraction, and modification methods of SF. In addition, it discusses SF's regulation of cell behavior and its various processing modes. Finally, the applications of SF in TE and perspectives on future developments are presented. This review provides comprehensive and alternative rational insights for further biomedical translation in SF medical device design, further revealing the great potential of SF biomaterials.

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组织工程用丝基生物材料。
组织工程(TE)涉及通过结合细胞、生长因子和支架材料来修复、替换、再生或改善组织和器官的功能。其中,支架材料起着至关重要的作用。丝素蛋白(Silk fibrin, SF)是一种天然的生物聚合物,由于其化学组成和结构所决定的良好的生物降解性、生物相容性和力学性能,在TE领域得到了广泛的应用。本文综述了顺丰的结构、提取和改性方法。此外,还讨论了SF对细胞行为的调节及其各种加工模式。最后,介绍了顺丰在TE中的应用,并对未来的发展进行了展望。本综述为顺丰医疗器械设计的进一步生物医学翻译提供了全面的、可替代的理性见解,进一步揭示了顺丰生物材料的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
28.50
自引率
2.60%
发文量
175
审稿时长
31 days
期刊介绍: "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.
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