Tolerance during infection

IF 27.6 1区医学 Q1 IMMUNOLOGY Nature Immunology Pub Date : 2025-01-31 DOI:10.1038/s41590-025-02083-0

Stephanie Houston

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感染期间的耐受性

肠道中的抗原呈递细胞（apc）在诱导免疫抵抗入侵病原体和对食物和共生细菌的免疫耐受之间保持着微妙的平衡，但哪些apc有助于耐受以及感染期间这种变化如何尚不清楚。Canesso等人在《科学》杂志上发现，传统的1型树突状细胞（cDC1s）有助于食物特异性诱导外周调节性T细胞（pTreg），感染通过减少cDC1和rr γ T + APCs在肠系膜淋巴结（mln）中的抗原呈递来损害口服耐受性。cDC1、cDC2和RORγt+ APCs是MLNs中CD4+ T细胞的膳食抗原。cDC1s与pTreg细胞产生相关的基因表达增加，而cDC2s与T细胞活化相关的基因表达增加。在MHC-II敲除小鼠模型中，pTreg细胞的食物特异性分化在cDC1s中减少，而在缺乏MHC-II表达的cDC2s中则没有减少。委内瑞拉圆线虫感染小鼠后，pTreg细胞的食物特异性诱导减少，mln中cDC1或RORγt+ APCs的膳食抗原呈递几乎完全消失，cDC2s总数增加。总之，这些数据表明，在感染期间，由于cDC2s抗原呈递增加，cDC1和RORγt+ apc被阻止参与抗原呈递到饮食抗原特异性T细胞。原参考文献：Science https://doi.org/10.1126/science.ado5088 （2024）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.

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