Perioperative chemotherapy superior to preoperative chemoradiotherapy for locally advanced EAC

IF 82.2 1区医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2025-01-31 DOI:10.1038/s41571-025-00995-2

David Killock

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局部晚期EAC围手术期化疗优于术前放化疗

两种多模式治疗策略，围手术期化疗和术前放化疗，已被证明与单独手术相比，可提高局部晚期食管腺癌（EAC）患者的总生存期（OS）；然而，最佳方法一直不清楚。最新发表的III期ESOPEC试验结果证明了围手术期策略的优越性。在ESOPEC中，438例可切除的cT1-4aN +或cT2-4aN0 EAC患者被随机分配（1:1），接受术前和术后4个周期的氟尿嘧啶、亚叶酸钙、奥沙利铂和多西紫杉醇（FLOT）或术前放疗（41.4 Gy / 23次），同时每周卡铂和紫杉醇。OS是主要终点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.