Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Neuroscience Pub Date : 2025-01-31 DOI:10.1007/s12031-024-02226-2

Yaping Yan, Lanxiao Cao, Luyan Gu, Congying Xu, Jinyu Lu, Dayao Lv, Jun Tian, Xinzhen Yin, Jiali Pu, Baorong Zhang, Guohua Zhao

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Abstract

The objective of this study is to explore the association of common genetic variation of anxiety disorders and essential tremor (ET). We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 504 age and gender-matched healthy controls from eastern China using a MassARRAY system. The association between candidate variants and ET patients was evaluated using gene-based analysis. A total of 159 patients (33.3%) had anxiety. In genotypic analysis, rs708012 (in an intergenic region) in the dominant models was found to be significantly associated with ET (P < 0.001, OR = 0.605). In allelic analysis, the carriers of the C allele of NTRK2 rs1187280 (P = 0.027, OR = 0.626), T allele of TMEM106B rs3807866 (P = 0.030, OR = 1.287), and T allele of rs708012 (P < 0.001, OR = 0.679) occupy a larger proportion of ET patients compared with healthy controls. Anxiety-specific risk SNPs of TMEM106B rs3807866 increase the risk for ET, while two SNPs of NTRK2 rs1187280 and rs708012 show a protective role.

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特发性震颤患者焦虑障碍的常见遗传变异分析。

本研究的目的是探讨焦虑障碍和特发性震颤（ET）的常见遗传变异的关系。我们使用MassARRAY系统对来自中国东部的478名不相关的ET患者和504名年龄和性别匹配的健康对照者进行了25种焦虑特异性风险变异的基因分型。候选变异与ET患者之间的关联使用基于基因的分析进行评估。159例患者（33.3%）存在焦虑。在基因型分析中，发现优势模型中的rs708012（位于基因间区）与ET显著相关(P

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来源期刊

Journal of Molecular Neuroscience 医学-神经科学

CiteScore

6.60

自引率

3.20%

发文量

142

审稿时长

1 months

期刊介绍： The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.