Exploring the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress
Bo Wang, Peijie Liu, Xinhui Gao, Fengqi Yang, Jiarui Sun, Fengqin He
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引用次数: 0
Abstract
Background
Maternal behavior is a complex form of social conduct exhibited, which directly influences the brain development and emotional behavior of offspring. Studies have shown that stress significantly impacts maternal behavior, with the 5-HT (serotonin) system playing a crucial role in this process
Objective
This study aims to explore the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress, and to analyze the molecular mechanisms involved
Methods
Sprague-Dawley rats were divided into control, stress, and stress+omega-3 (500 mg/kg) groups. Depressive behaviors were assessed using the sucrose preference test and forced swimming test. The regulatory effects of Omega-3 on maternal behavior following stress were analyzed by measuring 5-HT levels, 5-HT receptors, 5-HT1A receptor expression, downstream cAMP levels, inflammatory markers (IL-1β, TNF-α, and IL-6), and oxidative stress responses (MDA levels)
Results
The stress group exhibited significant reductions in maternal behaviors, such as delayed pup retrieval and decreased licking time. Omega-3 supplementation effectively improved these abnormalities, enhancing maternal care and reducing violent behaviors. Mechanistically, omega-3 supplementation increased 5-HT and receptor expression, reduced inflammation and oxidative stress, and promoted neuronal function recovery
Conclusion
Omega-3 fatty acids can effectively mitigate the negative impact of chronic stress on maternal behavior. The underlying mechanisms involve the regulation of the 5-HT system and the reduction of neuroinflammation. This finding provides a theoretical basis for clinical interventions targeting stress-related maternal behavior disorders.
期刊介绍：
Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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