Fatal acute liver failure following norovirus gastroenteritis in a child: A case report

IF 4 3区 医学 Q1 INFECTIOUS DISEASES Journal of Infection and Public Health Pub Date : 2025-01-20 DOI:10.1016/j.jiph.2025.102675
Rabab Taha , Noura Elazhary , Sarah Alqhtani , Walaa Almansouri
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Abstract

Norovirus is the leading cause of acute gastroenteritis and rarely present with extra-intestinal manifestations. There are few reported cases of hepatitis following norovirus gastroenteritis, with no documented fatalities. We present a case of fatal acute hepatitis following norovirus gastroenteritis in a child. The patient was a previously healthy 6-year-old boy who presented with diarrhea, vomiting, and fever. He was admitted and treated supportively as a case of acute gastroenteritis. Despite treatment, he rapidly developed acute liver failure in the course of gastroenteritis. Other potential causes including drugs and other possible viral infections were ruled out, only norovirus was isolated from his stool. The patient’s liver function continued to deteriorate leading to fulminant liver failure and death within days.
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儿童诺如病毒胃肠炎致死性急性肝衰竭1例报告。
诺如病毒是急性胃肠炎的主要原因,很少有肠道外表现。诺如病毒肠胃炎引起肝炎的病例很少,没有死亡记录。我们提出一个病例致死性急性肝炎后诺如病毒胃肠炎的儿童。患者为既往健康的6岁男童,表现为腹泻、呕吐和发烧。他作为急性肠胃炎病例入院治疗。尽管接受了治疗,但他在胃肠炎过程中迅速发展为急性肝功能衰竭。排除了其他可能的原因,包括药物和其他可能的病毒感染,仅从其粪便中分离出诺如病毒。患者肝功能持续恶化,导致暴发性肝功能衰竭并在数天内死亡。
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来源期刊
Journal of Infection and Public Health
Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
13.10
自引率
1.50%
发文量
203
审稿时长
96 days
期刊介绍: The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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