Mapping Eye, Arm, and Reward Information in Frontal Motor Cortices Using Electrocorticography in Nonhuman Primates.

Abstract

Goal-directed reaches give rise to dynamic neural activity across the brain as we move our eyes and arms and process outcomes. High spatiotemporal resolution mapping of multiple cortical areas will improve our understanding of how these neural computations are spatially and temporally distributed across the brain. In this study, we used micro-electrocorticography (µECoG) recordings in two male monkeys performing visually guided reaches to map information related to eye movements, arm movements, and receiving rewards over primary motor cortex, premotor cortex, frontal eye field, and dorsolateral prefrontal cortex. Time-frequency and decoding analyses revealed that eye and arm movement information shifts across brain regions during a reach, likely reflecting shifts from planning to execution. Although eye and arm movement temporally overlapped, phase clustering analyses enabled us to resolve differences in eye and arm information across brain regions. This analysis revealed that eye and arm information spatially overlapped in motor cortex, which we further confirmed by demonstrating that arm movement decoding performance from motor cortex activity was impacted by task-irrelevant eye movements. Phase clustering analyses also identified reward-related activity in the prefrontal and premotor cortex. Our results demonstrate µECoG's strengths for functional mapping and provide further detail on the spatial distribution of eye, arm, and reward information processing distributed across frontal cortices during reaching. These insights advance our understanding of the overlapping neural computations underlying coordinated movements and reveal opportunities to leverage these signals to enhance future brain-computer interfaces.