Association between 5-HTRs gene polymorphism and alcohol use disorder in Han males from Yunnan, China

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY Alcohol Pub Date : 2025-05-01 Epub Date: 2025-01-29 DOI:10.1016/j.alcohol.2025.01.008

Kuan Li , Wei Wei , Yue Wang , Ning Zhang , Jianjun Bao , Xulan Zhang , Xinjian Zheng , Fei Zhao , Xiaopei Yang , Jiahui Peng , Changqing Gao , Shurong Zhong

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Abstract

Alcohol use disorder (AUD) has become a very serious medical and social problem. It is found that genetic polymorphisms of the 5-hydroxytryptamine receptors (5-HTRs) genes were associated with the risk of AUD. However, the results are controversial among different ethnic groups. At present, the correlation between 5-HTRs gene polymorphism and AUD in Han population from Yunnan Province remains unclear. In this study, 13 single nucleotide polymorphisms (SNPs) of HTR1B, HTR2A, HTR3A, HTR3B and HTR7 were detected by universal fluorescent probe technique. The CT genotype frequency of HTR3A rs1062613 was significantly higher in AUD case group than that in control group (P = 0.037, OR = 2.193, 95% CI: 1.048–4.366). The study indicated that the genetic polymorphisms of 5-HTRs were significantly associated with risk of AUD in Han male from Yunnan, China. In addition, this study further demonstrated the impact of alcohol on human health, especially liver damage, by analyzing the blood biochemical indicators of patients with AUD and combining them with their medical history.

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中国云南汉族男性 5-HTRs 基因多态性与酒精使用障碍的关系

酒精使用障碍（AUD）已经成为一个非常严重的医学和社会问题。发现5-羟色胺受体（5-HTRs）基因的遗传多态性与AUD的风险相关。然而，这一结果在不同的种族群体中存在争议。目前，云南汉族人群5-HTRs基因多态性与AUD的相关性尚不清楚。本研究采用通用荧光探针技术检测了HTR1B、HTR2A、HTR3A、HTR3B和HTR7的13个单核苷酸多态性（snp）。AUD病例组HTR3A rs1062613的CT基因型频率显著高于对照组（P = 0.037, OR = 2.193, 95% CI: 1.048 ~ 4.366）。研究表明，5-HTRs基因多态性与中国云南汉族男性患AUD的风险显著相关。此外，本研究通过分析AUD患者的血液生化指标，并结合患者的病史，进一步论证了酒精对人体健康的影响，尤其是对肝脏的损害。

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来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.