Benjamin Klein, J. Michelle Kahlenberg, Johann E. Gudjonsson
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引用次数: 0
Abstract
In a recent study, published in Nature, Nordmann et al. identified Janus kinase inhibitors (JAKi) as a new treatment option for life-threatening toxic epidermal necrolysis (TEN). They showed this through spatial proteomics on human skin samples combined with in vivo administration of JAKi in individuals with TEN, demonstrating rapid reepithelization and recovery of patients.1 As TEN has a high mortality rate (30–50%),2 this study offers a new avenue for targeted treatment.
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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