Safety of Hydroxychloroquine: What a Dermatologist Should Know

IF 8.8 1区 医学 Q1 DERMATOLOGY American Journal of Clinical Dermatology Pub Date : 2025-02-03 DOI:10.1007/s40257-025-00919-x
Luca Rapparini, Stephano Cedirian, Michelangelo La Placa, Bianca Maria Piraccini, Emanuel Raschi, Michela Starace
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Abstract

The unique immunomodulatory properties of hydroxychloroquine (HCQ) have attracted considerable interest beyond its use for malaria and rheumatological diseases, including a variety of dermatological conditions. Over recent years, especially after the coronavirus disease 2019 (COVID-19) pandemic, the prescription of HCQ has also significantly expanded, sometimes inappropriately, thus posing additional challenges on its optimal use, due to emerging safety issues. In this review, we provide dermatologists with the latest advancements on selected clinically relevant toxicities, namely retinopathy, pro-arrhythmia, cutaneous reactions, and neuropsychiatric effects. It is hoped this update can assist dermatologists to identify high-risk patients for tailored monitoring, screening, and risk minimization strategies, thus supporting safer HCQ prescribing.

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羟氯喹的安全性:皮肤科医生应该知道的。
羟氯喹(HCQ)独特的免疫调节特性已引起相当大的兴趣,不仅用于疟疾和风湿病,包括各种皮肤病。近年来,特别是在2019冠状病毒病(COVID-19)大流行之后,HCQ的处方也大幅扩大,有时是不适当的,因此由于新出现的安全性问题,对其最佳使用构成了额外的挑战。在这篇综述中,我们为皮肤科医生提供了一些临床相关毒性的最新进展,即视网膜病变、促心律失常、皮肤反应和神经精神效应。希望这一更新可以帮助皮肤科医生识别高危患者,进行量身定制的监测、筛查和风险最小化策略,从而支持更安全的HCQ处方。
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来源期刊
CiteScore
15.20
自引率
2.70%
发文量
84
审稿时长
>12 weeks
期刊介绍: The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.
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