Elevated Lp(a) and its association with cardiac fibrosis in group II pulmonary hypertension patients.

IF 1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2025-02-01 Epub Date: 2025-02-02 DOI:10.1080/14796678.2025.2460909

Arif Albulushi, Shabib Al-Asmi, Moosa Al-Abri, Hatem Al-Farhan

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引用次数: 0

Abstract

Background: Group II Pulmonary Hypertension (PH) secondary to Heart Failure with preserved Ejection Fraction (HFpEF) is associated with significant morbidity and mortality. Lipoprotein(a) [Lp(a)] is a novel biomarker implicated in cardiovascular pathology, yet its role in myocardial fibrosis within this population remains underexplored. This study investigates the association between elevated Lp(a) levels and cardiac fibrosis to improve understanding of its prognostic and diagnostic utility.

Methods: This retrospective cohort study included 100 patients with Group II PH secondary to HFpEF. Serum Lp(a) levels were quantified using enzymatic assays, and myocardial fibrosis was assessed using Cardiac Magnetic Resonance Imaging (CMR) techniques, including T1 mapping and late gadolinium enhancement (LGE). Statistical models adjusted for confounding factors.

Results: Elevated Lp(a) levels were significantly associated with increased myocardial extracellular volume (31% vs. 27%, p < 0.01), prolonged native T1 times, and increased odds of myocardial scar formation. Structural cardiac changes correlated with Lp(a) concentrations.

Conclusion: Elevated Lp(a) is a key marker of myocardial fibrosis and structural remodeling in Group II PH secondary to HFpEF. Routine Lp(a) measurement may enhance risk stratification and inform therapeutic strategies.

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II组肺动脉高压患者Lp(a)升高及其与心脏纤维化的关系

背景：II组肺动脉高压（PH）继发于心力衰竭并保留射血分数（HFpEF）与显著的发病率和死亡率相关。脂蛋白(a) [Lp(a)]是一种涉及心血管病理的新型生物标志物，但其在该人群心肌纤维化中的作用仍未得到充分研究。本研究探讨了Lp(a)水平升高与心脏纤维化之间的关系，以提高对其预后和诊断效用的理解。方法：本回顾性队列研究纳入100例继发于HFpEF的II组PH患者。采用酶法定量血清Lp(a)水平，采用心脏磁共振成像（CMR）技术评估心肌纤维化，包括T1制图和晚期钆增强（LGE）。统计模型调整混杂因素。结果：Lp(a)水平升高与心肌细胞外体积增加显著相关（31% vs. 27%）， p结论：Lp(a)升高是继发于HFpEF的II组PH心肌纤维化和结构重构的关键标志物。常规Lp(a)测量可加强风险分层，为治疗策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.