Post-operative injection of hydrolyzed collagen peptides shows anti-inflammatory effect in patients with femoroacetabular impingement improving the early recovery

IF 2.7 Q2 ORTHOPEDICS Journal of Experimental Orthopaedics Pub Date : 2025-01-31 DOI:10.1002/jeo2.70158

Enrico Tassinari, Andrea Minerba, Tommaso Basile, Alessio Bucciarelli, Francesco Traina, Brunella Grigolo, Stefano Zaffagnini, Eleonora Olivotto

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Abstract

Purpose

This study aimed to compare the use of cortisone (C), intra-articular injected at the end of hip arthroscopy in patients with femoroacetabular impingement (FAI), to a new Class III medical device based on hydrolyzed collagen peptides ‘PEPTYS’ (P) and, to investigate potential associations among preoperative symptoms and hip function, outcomes after arthroscopic surgery and presence of inflammatory biomarkers in synovial fluids (SFs) at basal condition.

Methods

The two treatments were administrated to patients scheduled for arthroscopy with simple blind randomization sampling. Based on the sample size calculation, the number necessary to recruit was at least 20 patients for the C group and 20 for the P group. SFs, when available, were obtained by aspiration just prior to surgical intervention. At the baseline, osteoarthritis (OA) severity was assessed with a radiographic scoring system (Tönnis classification). Physical examination and clinical assessment using the Hip disability and Osteoarthritis Outcome Score (HOOS) and visual analogue scale (VAS) score for pain were performed at the time of surgery and at 1 and 6 months of follow-up. At the time of surgery, chondral (Outerbridge score) and labral pathology based on direct arthroscopic visualization were also evaluated.

Results

Forty-seven FAI patients were enroled, with a median age of 35 years with a standard deviation (SD) of 10.6 and a body mass index of 24.3kg/m² with an SD of 4.5. 24 patients were treated with C and 23 with P. Both treatments did not show any statistically significant difference in hip function and pain. High expression of inflammatory molecules in SFs was correlated with the worst post-operative articular function.

Conclusions

Our study showed that the use of P was completely comparable to cortisone. Therefore, PEPTYS might be a valuable candidate to improve early recovery, in terms of pain and function, from arthroscopic FAI treatment.

Level of Evidence

Level III, comparative and randomized study.

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股骨髋臼撞击患者术后注射水解胶原肽具有抗炎作用，促进早期康复。

目的：本研究旨在比较股骨髋臼撞击（FAI）患者在髋关节镜检查结束时关节内注射可的松(C)与基于水解胶原肽“PEPTYS”(P)的新型III类医疗器械的使用，并研究术前症状和髋关节功能、关节镜手术后的结果以及基础状态下滑膜液（sf）中炎症生物标志物的存在之间的潜在关联。方法：采用简单盲随机抽样方法，对拟行关节镜检查的患者进行两种治疗。根据样本量计算，C组至少需要招募20例患者，P组至少需要招募20例患者。SFs，如果有的话，是在手术介入前通过抽吸获得的。基线时，骨性关节炎（OA）的严重程度通过x线评分系统（Tönnis分类）进行评估。采用髋关节残疾和骨关节炎结局评分（HOOS）和视觉模拟评分（VAS）对疼痛进行体格检查和临床评估，并在手术时和随访1个月和6个月时进行。在手术时，软骨（Outerbridge评分）和基于直接关节镜可视化的唇部病理也进行了评估。结果：纳入47例FAI患者，中位年龄为35岁，标准差（SD）为10.6，体重指数为24.3kg/m²，SD为4.5。24例患者接受C治疗，23例接受p治疗，两种治疗在髋关节功能和疼痛方面均无统计学差异。sf中炎症分子的高表达与术后最差的关节功能相关。结论：我们的研究表明，P的使用与可的松完全相当。因此，就关节镜下FAI治疗的疼痛和功能而言，PEPTYS可能是改善早期恢复的有价值的候选药物。证据等级：III级，比较和随机研究。

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