The effective normal tissue non-complication probability (E0): a probabilistic methodology in the representation of the stochastic health safety effects of low levels of ionizing radiation on the human tissues or organs.

IF 2.4 International journal of radiation biology Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI:10.1080/09553002.2025.2459098
Terman Frometa-Castillo, Anil Pyakuryal, Ganesh Narayanasamy, Terence Sio
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Abstract

Purpose: 1) To discontinue gradually the current non-probabilistic equivalent dose (E) methodology in the radiation protection (RP) with our proposed E0(HN) one; HN is H set of all tissue or organs (ToOs) irradiated. E0 is directly associated with probability of non-harmful effects of low levels of ionizing radiation; 2) To apply the radiation oncology normal tissue non-complication probability (NTCP0) methodology for evaluations in other radiation activity (RAs); and 3) To apply the SMp(x) function in the graphical models of UNSCEAR in order to a) To establish the lower limit of the 100%-risk deterministic region, i.e. 0%-safety deterministic one; b) To correct the representation of the "Hormetic" model; and c) To express with mathematical formulas these models. The two first aspects will represent corrections for these graphical models.

Methods: Radiobiological-probabilistic studies aimed to represent the stochastic health safety to the ToOs using NTCP0 and E0 as inherent probabilistic concepts.

Conclusion: The E0 methodology will represent to eliminate gradually the current E one, Sv, rem and expressing equivalent dose (H) in Gy. This study will push: 1) Improvements over the UNSCEAR graphical models; and 2) To extend to all RAs the NTCP0 methodology.

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有效正常组织无并发症概率(E0):表示低水平电离辐射对人体组织或器官的随机健康安全影响的概率方法。
目的:1)在辐射防护(RP)中逐步停止现行的非概率等效剂量(E)方法,采用我们提出的E0(HN)方法;HN是所有组织或器官(ToOs)的H组。E0与低水平电离辐射产生无害影响的可能性直接相关;2)应用放射肿瘤学正常组织无并发症概率(NTCP0)方法评价其他放射活性(RAs);3)在UNSCEAR图形模型中应用SMp(x)函数,以便:a)建立100%风险确定性区域的下限,即0%安全确定性区域;b)修正“Hormetic”模型的表示;c)用数学公式表示这些模型。前两个方面将表示对这些图形模型的修正。方法:放射生物学-概率研究旨在用NTCP0和E0作为固有概率概念来表示对ToOs的随机健康安全性。结论:E0方法学将代表逐步消除当前的e1、Sv、rem,并以Gy表示等效剂量(H)。这项研究将推动:1)改进辐射科委会的图形模型;2)将NTCP0方法推广至所有认可机构。
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