Top-Down Assembly of Photosensitizable Flexible Wood Dressing with Synergistic Effect of Anti-Infection and Moisture Management

Abstract

Infected wound repair stands as a formidable global issue, posing significant threats to public health and medical care. Biopolymer-based dressings represent a natural and biocompatible candidate greatly conductive to wound healing. However, the low productivity and high price, coupled with the widespread lack of antibacterial activities, vitally restrict their clinical applications. Herein, a simple yet efficient top-down assembly strategy is reported to fabricate aggregation-induced emission photosensitizer (AIE-PS) functionalized flexible wood (AIE/FW) dressing with synergistic photodynamic therapy and moisture management to accelerate the healing of infected wounds. On account of its superior bactericidal effectiveness and appropriate moisture management, along with superb flexibility and excellent biocompatibility, the proposed AIE/FW can effectively prevent wound infection and alleviate inflammatory response, thereby dramatically boosting the infected wound recovery. It is anticipated that the scalable, sustainable, and cost-effective AIE/FW offers a promising pathway to overcome global wound care challenges.