A General Strategy for Tumor-Specific In Situ Synthesis of Copper Sulfide for Gas Therapy and Surface Plasmon Resonance Enhanced Phototherapy

IF 8.7 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2024-12-09 DOI:10.1021/acsmaterialslett.4c01803

Wei Cheng, Ying Wu, Bowen Li, Lichao Su, Min Wu, Luntao Liu, Shuhan Wang, Chunhua Lu* and Bin Liu*,

{"title":"A General Strategy for Tumor-Specific In Situ Synthesis of Copper Sulfide for Gas Therapy and Surface Plasmon Resonance Enhanced Phototherapy","authors":"Wei Cheng, Ying Wu, Bowen Li, Lichao Su, Min Wu, Luntao Liu, Shuhan Wang, Chunhua Lu* and Bin Liu*, ","doi":"10.1021/acsmaterialslett.4c01803","DOIUrl":null,"url":null,"abstract":"CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu2O can be converted in situ to CuS through sulfurization by H2S in tumor cells. However, this approach is currently limited to colon cancer because other tumors exhibit comparatively lower H2S concentrations. Herein, we reported a nanoplatform consisting of two key components, diallyl trisulfide (DATS) and Cu2O-coated nanogapped gold nanoparticle (AuNNP). DATS reacted with upregulated glutathione (GSH) in tumor cells to release H2S for gas therapy as well as the sulfurization of Cu2O. AuNNPs further enhanced the photothermal and photodynamic effect of the in situ-formed CuS via surface plasmon resonance effect. Both H2S-induced gas therapy and CuS-mediated photothermal/photodynamic therapy exhibited much higher toxicity to tumor cells than to normal cells. Given that GSH is typically overexpressed in cancer cells, the developed strategy is thus generally applicable for almost any tumors.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"7 1","pages":"181–192 181–192"},"PeriodicalIF":8.7000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c01803","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu₂O can be converted in situ to CuS through sulfurization by H₂S in tumor cells. However, this approach is currently limited to colon cancer because other tumors exhibit comparatively lower H₂S concentrations. Herein, we reported a nanoplatform consisting of two key components, diallyl trisulfide (DATS) and Cu₂O-coated nanogapped gold nanoparticle (AuNNP). DATS reacted with upregulated glutathione (GSH) in tumor cells to release H₂S for gas therapy as well as the sulfurization of Cu₂O. AuNNPs further enhanced the photothermal and photodynamic effect of the in situ-formed CuS via surface plasmon resonance effect. Both H₂S-induced gas therapy and CuS-mediated photothermal/photodynamic therapy exhibited much higher toxicity to tumor cells than to normal cells. Given that GSH is typically overexpressed in cancer cells, the developed strategy is thus generally applicable for almost any tumors.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

用于气体治疗和表面等离子体共振增强光疗的肿瘤特异性原位合成硫化铜的一般策略

cu纳米材料因其优异的光热和光动力特性在肿瘤治疗中受到广泛关注。值得注意的是，在肿瘤细胞中，Cu2O可以通过H2S的硫化原位转化为cu。然而，这种方法目前仅限于结肠癌，因为其他肿瘤的H2S浓度相对较低。在此，我们报道了一个由两种关键成分组成的纳米平台，二烯丙基三硫化物（DATS）和cu20涂层纳米缺口金纳米颗粒（AuNNP）。DATS与肿瘤细胞中上调的谷胱甘肽（GSH）反应，释放H2S用于气体治疗以及Cu2O的硫化。AuNNPs通过表面等离子体共振效应进一步增强了原位形成的cu的光热和光动力效应。h2s诱导的气体疗法和cu介导的光热/光动力疗法对肿瘤细胞的毒性均高于对正常细胞的毒性。鉴于谷胱甘肽通常在癌细胞中过度表达，因此开发的策略通常适用于几乎所有肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.