A General Strategy for Tumor-Specific In Situ Synthesis of Copper Sulfide for Gas Therapy and Surface Plasmon Resonance Enhanced Phototherapy

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2024-12-09 DOI:10.1021/acsmaterialslett.4c0180310.1021/acsmaterialslett.4c01803

Wei Cheng, Ying Wu, Bowen Li, Lichao Su, Min Wu, Luntao Liu, Shuhan Wang, Chunhua Lu* and Bin Liu*,

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Abstract

CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu₂O can be converted in situ to CuS through sulfurization by H₂S in tumor cells. However, this approach is currently limited to colon cancer because other tumors exhibit comparatively lower H₂S concentrations. Herein, we reported a nanoplatform consisting of two key components, diallyl trisulfide (DATS) and Cu₂O-coated nanogapped gold nanoparticle (AuNNP). DATS reacted with upregulated glutathione (GSH) in tumor cells to release H₂S for gas therapy as well as the sulfurization of Cu₂O. AuNNPs further enhanced the photothermal and photodynamic effect of the in situ-formed CuS via surface plasmon resonance effect. Both H₂S-induced gas therapy and CuS-mediated photothermal/photodynamic therapy exhibited much higher toxicity to tumor cells than to normal cells. Given that GSH is typically overexpressed in cancer cells, the developed strategy is thus generally applicable for almost any tumors.

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.

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