Immune Cells as Trojan Horses for Cancer Nanotherapy

IF 8.7 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2024-12-08 DOI:10.1021/acsmaterialslett.4c01523

Cristina Hermosillo-Abundis, Jessica Andrea Flood-Garibay, Vanesa Ayala-Nunez* and Miguel Angel Méndez-Rojas*,

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Abstract

Nanotechnology is a promising strategy in the fight against cancer by leveraging the unique properties of nanomaterials for targeted drug delivery. A significant challenge in this domain is overcoming biological barriers and ensuring precise delivery to tumor sites. Immune cells, inherently adept at navigating the body’s defense systems and homing to tumor sites, present an excellent solution as Trojan horses for cancer nanotherapy. This review explores the utilization of immune cells as carriers or mediators of nanoparticle-based therapeutics. The Trojan horse strategy is presented in the context of nanomedicine and cancer, followed by a discussion of its advantages. Next, the diversity of nanoparticle systems that have shown positive therapeutic outcomes in preclinical studies is explored. The challenges of using immune cells as Trojan horses, such as nanoparticle loading and manipulation, are analyzed. Finally, strategies for fine-tuning nanoparticles to design an effective Trojan horse approach are suggested. By synthesizing current research findings, this review underscores the potential of nanotechnology in combination with immune cells for innovative and effective cancer treatments.

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免疫细胞作为癌症纳米治疗的特洛伊木马

纳米技术是一种很有前途的抗癌策略，它利用纳米材料的独特特性来靶向给药。该领域的一个重大挑战是克服生物屏障并确保精确递送到肿瘤部位。免疫细胞天生擅长驾驭身体的防御系统，并定位到肿瘤部位，作为癌症纳米治疗的特洛伊木马，提供了一个极好的解决方案。这篇综述探讨了利用免疫细胞作为载体或介质的纳米颗粒为基础的治疗。特洛伊木马策略是在纳米医学和癌症的背景下提出的，随后讨论了其优势。接下来，探讨了在临床前研究中显示出积极治疗效果的纳米颗粒系统的多样性。分析了利用免疫细胞作为特洛伊木马的挑战，如纳米颗粒的装载和操作。最后，提出了纳米粒子的微调策略，以设计有效的特洛伊木马方法。通过综合目前的研究成果，本综述强调了纳米技术与免疫细胞结合的潜力，用于创新和有效的癌症治疗。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.