A fluorescent probe for selective detection of Pd2+ combined with fluorescent composite membranes and bioimaging

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchemical Journal Pub Date : 2025-01-01 DOI:10.1016/j.microc.2024.112370

Haohu Li , Wen Li , Xinjie Yang , Li Liu , Haiyang Guo , Xijuan Chai , Linkun Xie , Kaimeng Xu , Guanben Du , Lianpeng Zhang

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Abstract

Palladium, as a transition metal of the platinum group elements, plays an indispensable role in chemical, pharmaceutical, and industrial production. However, its potential toxicity can pose risks to our health and the environment. In this work, a novel parallel alkyne-amine naphthalene ring fluorescent probe LNA based on Pd²⁺ coordination has been developed. The basic structure and detection mechanism of the probe have been confirmed by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), and liquid chromatography-mass spectrometry (LC-MS). The probe LNA has a fluorescence-off response to the Pd²⁺ with high sensitivity (as fast as 60 s) and excellent selectivity (with a detection limit as low as 0.12 μM). Due to the outstanding fluorescence properties of LNA and the low cytotoxicity of its ligand complexes, it has been successfully applied to carboxymethyl cellulose-based fluorescent composite membranes as well as Pd²⁺ imaging of living cells.

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一种结合荧光复合膜和生物成像的选择性检测Pd2+的荧光探针

钯作为铂族元素的过渡金属，在化工、医药和工业生产中起着不可缺少的作用。然而，它的潜在毒性会对我们的健康和环境构成威胁。本文研制了一种新型的基于Pd2+配位的平行炔胺萘环荧光探针LNA。通过核磁共振（NMR）、傅里叶变换红外光谱（FTIR）和液相色谱-质谱（LC-MS）等手段证实了探针的基本结构和检测机理。探针LNA对Pd2+具有高灵敏度（最快可达60 s）和良好的选择性（检测限低至0.12 μM）的荧光关闭响应。由于LNA具有突出的荧光特性和其配体复合物的低细胞毒性，已成功应用于羧甲基纤维素基荧光复合膜以及活细胞的Pd2+成像。

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来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.