Maillard reaction-based conjugates as carrier strategies for delivery of bioactive compounds: A review

IF 9.1 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Current Opinion in Food Science Pub Date : 2025-02-01 Epub Date: 2024-12-10 DOI:10.1016/j.cofs.2024.101260
Yumeng Zhang, Yuanfang Xie, Junhua Shao, Xiqing Yue, Mohan Li
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Abstract

Bioactive compounds (BCs) have long been hindered by multiple barriers in the gastrointestinal tract (GIT) preventing effective absorption. Thus, in order to further enhance the bioavailability of BCs, delivery systems consisting of conjugates using the Maillard reaction as carriers are gradually coming into the limelight. Since BCs are challenging for delivery in GIT, the delivery and release of BCs in this review will be updated and discussed based on the carriers of the Maillard conjugates. The focus includes emulsions, nanoparticles, microcapsules, gels, liposomes, and solid lipid nanoparticles. Upon this, the application of Maillard conjugates offers the possibility of targeted release of BCs in vivo and their protection. This review offers insights into delivery systems designed that improve bioavailability.
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基于美拉德反应的缀合物作为递送生物活性化合物的载体策略:综述
长期以来,生物活性化合物(bc)一直受到胃肠道(GIT)多种屏障的阻碍,无法有效吸收。因此,为了进一步提高bc的生物利用度,以美拉德反应为载体的缀合物组成的递送系统逐渐成为人们关注的焦点。由于BCs在GIT中的交付具有挑战性,因此本文将根据美拉德共轭物的载体更新和讨论BCs的交付和发布。重点包括乳液,纳米颗粒,微胶囊,凝胶,脂质体和固体脂质纳米颗粒。在此基础上,美拉德偶联物的应用提供了在体内靶向释放bc及其保护的可能性。这篇综述为提高生物利用度的给药系统设计提供了见解。
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来源期刊
Current Opinion in Food Science
Current Opinion in Food Science Agricultural and Biological Sciences-Food Science
CiteScore
18.40
自引率
4.00%
发文量
157
审稿时长
92 days
期刊介绍: Current Opinion in Food Science specifically provides expert views on current advances in food science in a clear and readable format. It also evaluates the most noteworthy papers from original publications, annotated by experts. Key Features: Expert Views on Current Advances: Clear and readable insights from experts in the field regarding current advances in food science. Evaluation of Noteworthy Papers: Annotated evaluations of the most interesting papers from the extensive array of original publications. Themed Sections: The subject of food science is divided into themed sections, each reviewed once a year.
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