Higher-order adaptive dynamical system modelling of epigenetic mechanisms in infant temperament shaped by prenatal maternal stress

Abstract

Prenatal maternal stress (PNMS) has significant implications for infant temperament, primarily through alterations in the hypothalamic–pituitary–adrenal (HPA) axis and epigenetic mechanisms. This study explores the effects of PNMS on infant stress reactivity using a fifth-order adaptive dynamical system model. The model integrates genetic, epigenetic, and environmental factors, focusing on the downregulation of 11β-HSD-2, an enzyme responsible for converting active cortisol to its inactive form, and its subsequent influence on fetal cortisol exposure. The article also employs network-oriented modeling to represent epigenetic changes and their impact on infant temperament development, emphasizing the HPA axis’ role in stress regulation. Simulation experiments compare scenarios with PNMS, illustrating the long-term developmental consequences on temperament. This research highlights the importance of maternal well-being during pregnancy in shaping infant stress responses and provides insights into the developmental origins of health and disease.