Comment on “l-Proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: regioselective synthesis of 5-arylpyrimido[4,5-b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in water” by A. Khalafi-Nezhad, S. Sarikhani, E. Shaikhi Shahidzadeh and F. Panahi, Green Chem., 2012, 14, 2876†
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引用次数: 0
Abstract
The title paper reported a green and efficient one-pot method for synthesizing 5-aryl-pyrimido[4,5-b]quinoline-dione derivatives via a three-component reaction involving anilines, aldehydes and barbituric acids. However, these starting materials can theoretically yield two possible structural variants. Under the same reaction conditions as the title paper, the 1H NMR spectrum of the synthesized compound (4f) provided data that challenge the structural assignment of the proposed target compound.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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