A Silicon-Pixel Paradigm for PET

IF 3.5 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2024-09-09 DOI:10.1109/TRPMS.2024.3456241

Aleix Boquet-Pujadas;Jihad Saidi;Mateus Vicente;Lorenzo Paolozzi;Jonathan Dong;Pol Del Aguila Pla;Giuseppe Iacobucci;Michael Unser

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Abstract

Positron emission tomography (PET) scanners use scintillation crystals to stop high-energy photons. The ensuing lower-energy photons are then detected via photomultipliers. We study the performance of a stack of monolithic silicon-pixel detectors as an alternative to the combination of crystals and photomultipliers. The resulting design allows for pitches as small as

$100~ {\mu }$

m and greatly mitigates depth-of-interaction problems. We develop a theory to optimize the sensitivity of these and other scanners under design constraints. The insight is complemented by Monte Carlo simulations and reconstructions thereof. Experiments and theory alike suggest that our approach has the potential to move PET closer to the microscopic scale. The volumetric resolution is an order of magnitude better than that of the state of the art and the parallax error is very small. A small-animal scanner is now under construction.

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PET的硅像素范式

正电子发射断层扫描（PET）扫描仪使用闪烁晶体来阻止高能光子。随后的低能量光子通过光电倍增管被探测到。我们研究了一堆单片硅像素探测器的性能，作为晶体和光电倍增管组合的替代方案。最终的设计允许小到$100~ {\mu}$ m的投球，并大大减轻了深度交互问题。我们开发了一种理论来优化这些和其他扫描仪在设计约束下的灵敏度。这一见解得到了蒙特卡罗模拟和重建的补充。实验和理论都表明，我们的方法有可能使PET更接近微观尺度。体积分辨率是一个数量级比国家的艺术和视差误差是非常小的。小型动物扫描仪正在建设中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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